RSC Chem. Biol.
 2021
DOI: 10.1039/d0cb00209g
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Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity

Nicholas J. Cundy
1
,
Roseanna K. Hare
2
,
Tina Tang
3
et al.

Abstract: We report the rational design, novel syntheses and biophysical and in silico evaluation of tryptophan-inspired tool compounds to probe the illusive MOA of the clinically-relevant heme-dioxygenase protein, IDO1.

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