Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain

Kong, Dehui; Saqer, Alaa A.; Jesus, Matheus Carpinelli de; Khan, Nemat; Jones, Alun; Blanchfield, Joanne T.; Smith, M. T.; Williams, Craig M.

doi:10.1016/j.bmc.2022.116889

Cited by 5 publications

(3 citation statements)

References 48 publications

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“…The achievements of LA supplementation to date are exciting, but the evidence is heavily limited primarily by the short duration of the trial and insufficient research. Researchers also consider its supplementation in terms of low bioavailability after oral administration, which is a key factor preventing its use [45]. Cameron et al compared gastrointestinal tolerance and assessed R-lipoic acid (LA) absorption in subjects with progressive multiple sclerosis in a single-center, randomized, double-blind, crossover study.…”

Section: Alpha-lipoic Acidmentioning

confidence: 99%

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Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Zielińska¹,

Michońska²

2022

ppn

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Purpose: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system in which multifocal damage to the brain and spinal cord occurs. The etiology of MS remains unclear but it is often recognized by researchers as a multifactorial disease that involves autoimmune and genetic predisposition combined with environmental influences (e.g., low vitamin D levels, smoking, obesity). An adequate and balanced diet can be extremely helpful in improving the condition of MS patients, effectively supporting pharmacological therapy. The purpose of the study was to investigate whether, and if so, to what extent, the intake of macronutrients, vitamins, and microelements may affect the course of MS. Views: The review presents data from studies published between 2017 and 2022. Conclusions: There are numerous studies on the role of specific dietary components in the treatment of MS, but the results are still limited. More work is needed to define the tools required for the assessment of patients' eating habits because dietary factors can affect the functioning and quality of life of MS patients and should therefore be evaluated to assist in comprehensive treatment and recovery.

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Section: Alpha-lipoic Acidmentioning

confidence: 99%

Section: Fatsmentioning

confidence: 99%

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Zielińska¹,

Michońska²

2022

ppn

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“…In this context, the use of ammonium salts has been demonstrated in acetalization reactions by our group, [35] where ammonium bromide and ammonium hydrogensulfate proved to be an efficient and cheap alternative to many other homogeneous or heterogeneous catalysts, easy to handle and recover without posing problem of corrosion and toxicity. Considering the importance of glycerol acetals as flavors, [36] fuel additives [37] and intermediates in the synthesis of fine chemicals and drugs, [38][39][40][41] their synthesis based on mild and non-toxic catalysts in an environmentally sustainable solvent is highly desirable. In the present work, a system based on ammonium salts in CPME was applied to obtain glycerol acetals in a sustainable way.…”

Section: Introductionmentioning

confidence: 99%

Glycerol Acetalization in Cyclopentyl Methyl Ether with Mild Acid Catalysts

et al. 2023

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Reaction of glycerol with aldehydes and ketones is a strategy widely studied in literature to valorize this bioproduct. A Brønsted or Lewis acid is normally used to activate the carbonyl function and various strategies adopted to drive the equilibrium to the products. In this study ammonium salts as catalysts, and removal of water by azeotropic distillation of cyclopentyl methyl ether, permit the conversion of glycerol into acetals obtained as mixture of dioxanes and dioxolanes determined by 1H‐NMR. Under the optimized conditions, the products could be obtained in excellent yield without using excess of reactants and the solvent was recycled efficiently.

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Establishment of purification techniques for alpha-lipoic acid derivative, sodium zinc histidine dithiooctanamide using ethanol-based crystallization and suspension methods

Ohmori,

Miyagi,

Nakano

et al. 2024

J IRAN CHEM SOC

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Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain

Cited by 5 publications

References 48 publications

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Glycerol Acetalization in Cyclopentyl Methyl Ether with Mild Acid Catalysts

Establishment of purification techniques for alpha-lipoic acid derivative, sodium zinc histidine dithiooctanamide using ethanol-based crystallization and suspension methods

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