Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents

Song, Di; Zhang, Nan; Zhang, Panpan; Zhang, Na; Chen, Weijin; Zhang, Long; Guo, Ting; Gu, Xiaotong; Ma, Shutao

doi:10.1016/j.ejmech.2021.113480

Cited by 24 publications

(4 citation statements)

References 50 publications

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“…FtsZ forms a ring at the site of cell division that generates a constriction force ( 86 ). FtsZ is regulated by the Rcs system ( 87 ), although a clear role for this essential protein in biofilm formation is also difficult to discern due to its impact on viability ( 88 – 90 ).…”

Section: Our Current Understanding: Models For Surface Sensing In Bac...mentioning

confidence: 99%

The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa

2022

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Section: Our Current Understanding: Models For Surface Sensing In Bac...mentioning

confidence: 99%

The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa

2022

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“…The propensity of bacterial resistance development for 21d was evaluated using a multi-generation resistance selection assay ( Song et al, 2021 ). The initial MIC of 21d against S. pneumoniae (ATCC49619) was determined by the antibacterial activity evaluation described above.…”

Section: Multigeneration Resistance Selection Assaymentioning

confidence: 99%

Synthesis and Biological Evaluation of 3-(Pyridine-3-yl)-2-Oxazolidinone Derivatives as Antibacterial Agents

et al. 2022

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In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives was designed, synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic, morphological, kinetic studies, and molecular docking. The results demonstrated that compounds 21b, 21d, 21e and 21f exhibited strong antibacterial activity similar to that of linezolid toward five Gram-positive bacteria. After observing the effect of the drug on the morphology and growth dynamics of the bacteria, the possible modes of action were predicted by molecular docking. Furthermore, the antibiofilm activity and the potential drug resistance assay was proceeded. These compounds exhibited universal antibiofilm activity and compound 21d showed significant concentration-dependent inhibition of biofilm formation. Compound 21d also showed a stable effect on S. pneumoniae (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents.

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“…In addition, SAN extracted from the herb medicine Macleaya cordata had a broad-spectrum antibacterial effect, especially the significant antibacterial effect on both S. aureus and methicillin-resistant S. aureus. [23] It was worth noting that the antibacterial effect of SAN was superior to that of the star natural antibacterial drug berberine. SAN has also been widely used in animal feed additives and antibacterial toothpaste because of its outstanding bacteriostatic effect.…”

Section: Introductionmentioning

confidence: 99%

Natural Carrier‐Free Binary Small Molecule Self‐Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response

Wang

Yuan

et al. 2022

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Methicillin‐resistant Staphylococcus aureus (MRSA)‐infected skin wounds have caused a variety of diseases and seriously endanger global public health. Therefore, multidimensional strategies are urgently to find antibacterial dressings to combat bacterial infections. Antibacterial hydrogels are considered potential wound dressing, while their clinical translation is limited due to the unpredictable risks and high costs of carrier excipients. it is found that the natural star antibacterial and anti‐inflammatory phytochemicals baicalin (BA) and sanguinarine (SAN) can directly self‐assemble through non‐covalent bonds such as electrostatic attraction, π–π stacking, and hydrogen bonding to form carrier‐free binary small molecule hydrogel. In addition, BA‐SAN gel exhibited a synergistic inhibitory effect on MRSA. And its plasticity and injectability allowed it to be applied as a wound dressing. Due to the matched physicochemical properties and synergistic therapeutic effects, BA‐SAN gel can inhibit bacterial virulence factors, alleviate wound inflammation, promote wound healing, and has good biocompatibility. The current study not only provided an antibacterial hydrogel with clinical value but also opened up new prospects that carrier‐free hydrogels can be designed and originated from clinically used small‐molecule phytochemicals.

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Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents

Cited by 24 publications

References 50 publications

The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa

The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa

Synthesis and Biological Evaluation of 3-(Pyridine-3-yl)-2-Oxazolidinone Derivatives as Antibacterial Agents

Natural Carrier‐Free Binary Small Molecule Self‐Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response

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