Design, Synthesis and Photodynamic Antimicrobial Activity of Ruthenium Trischelate Diimine Complexes

Donnelly, Ryan F.; Fletcher, Nicholas C.; McCague, Paul; Donnelly, John A.; McCarron, Paul A.; Tunney, M.M.

doi:10.2174/157018007780077390

Cited by 28 publications

(22 citation statements)

References 13 publications

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“…Polypyridyl ruthenium(II) complexes with specific photophysical properties could achieve their microbiological effects via photodynamic antimicrobial chemotherapy (PACT). Donnelly and coworkers described, for the first time, that ruthenium(II) complex ([Ru(dmob) 3 ]Cl 2 ), with dmob = 4,4′-dimethoxy-2,2′-bipyrdine, could serve as a photosensitiser for use in PACT [54]. As a result, the photosensitizer exhibited toxic effects on microorganisms that could be intensified remarkably via irradiation.…”

Section: Polypyridyl Ruthenium(ii) Complexes With Different Structmentioning

confidence: 99%

Recent Advances on Octahedral Polypyridyl Ruthenium(II) Complexes as Antimicrobial Agents

Yang

Liao

2018

Polymers

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Recent developments of therapeutic agents based on transition metals have attracted a great deal of attention. Metal drugs have advantages over other small molecule drugs, and it was demonstrated that, in a number of studies, they played an important role in pharmaceutical chemical research and clinical chemotherapy of cancers. It is worthwhile mentioning that octahedral polypyridyl ruthenium(II) complexes have shown remarkable applications in chemical biology and medicinal chemistry over the last decade. However, only very recently has there been comprehensive interest in their antimicrobial properties due to metal-related toxic concerns or neglected potential roles in microbiological systems. Our review will highlight the recent developments in octahedral polypyridyl ruthenium(III) complexes that have exhibited significant antimicrobial activities and will discuss the relationship between the chemical structure and biological process of ruthenium complexes, in both bacterial and fungal cells.

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Section: Polypyridyl Ruthenium(ii) Complexes With Different Structmentioning

confidence: 99%

Recent Advances on Octahedral Polypyridyl Ruthenium(II) Complexes as Antimicrobial Agents

Yang

Liao

2018

Polymers

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“…However, research on the antimicrobial activity of Ru(II) polypyridyl complexes upon light irradiation is still in its infancy. Only a few articles in the field of aPDT reported on the photo-inactivation of microorganisms by these types of complexes [ 26 , 27 , 28 , 29 ], taking benefits from the large variety of Ru(II) polypyridyl complexes developed for cancer treatment [ 30 ]. These studies highlighted the importance of lipophilicity, charge, and charge separation of molecules on antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy

et al. 2020

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Antimicrobial photodynamic therapy (aPDT) also known as photodynamic inactivation (PDI) is a promising strategy to eradicate pathogenic microorganisms such as Gram-positive and Gram-negative bacteria. This therapy relies on the use of a molecule called photosensitizer capable of generating, from molecular oxygen, reactive oxygen species including singlet oxygen under light irradiation to induce bacteria inactivation. Ru(II) polypyridyl complexes can be considered as potential photosensitizers for aPDT/PDI. However, to allow efficient treatment, they must be able to penetrate bacteria. This can be promoted by using nanoparticles. In this work, ruthenium-polylactide (RuPLA) nanoconjugates with different tacticities and molecular weights were prepared from a Ru(II) polypyridyl complex, RuOH. Narrowly-dispersed nanoparticles with high ruthenium loadings (up to 53%) and an intensity-average diameter < 300 nm were obtained by nanoprecipitation, as characterized by dynamic light scattering (DLS). Their phototoxicity effect was evaluated on four bacterial strains (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa) and compared to the parent compound RuOH. RuOH and the nanoparticles were found to be non-active towards Gram-negative bacterial strains. However, depending on the tacticity and molecular weight of the RuPLA nanoconjugates, differences in photobactericidal activity on Gram-positive bacterial strains have been evidenced whereas RuOH remained non active.

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“…These complexes also exhibit antimicrobial activity against drug‐resistant pathogenic microorganisms which cause malaria and Chagas disease. The antimicrobial activity increases in the case of antibiotic agents which are directly coordinated to ruthenium centre ,…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Photophysical and Electrochemical Studies of Ruthenium(II) Complexes with 4′‐Substituted Terpyridine Ligands and Their Biological Applications

Ezhilarasu

Balasubramanian

2018

ChemistrySelect

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Three 4′‐(4‐Methylbenzoate‐benzyloxy)‐2,2′:6′,2′′‐terpyridine (MBBtpy), 4′‐(4‐Ethylbenzoate‐benzyloxy)‐2,2′:6′,2′′‐terpyridine (EBBtpy) and 4′‐(5‐(1,3‐Dimethylbenzoate)‐benzyloxy)‐2,2′:6′,2′′‐terpyridine (DMBBtpy) ligands and seven ruthenium(II) symmetrical [Ru(MBBtpy)2](PF6)2 (Ru1), [Ru(EBBtpy)2](PF6)2 (Ru2), [Ru(DMBBtpy)2](PF6)2 (Ru3) and unsymmetrical [Ru(MBBtpy)(EBBtpy)](PF6)2 (Ru4), [Ru(MBBtpy)(ttpy)](PF6)2 (Ru5), [Ru(MBBtpy)(Brttpy)](PF6)2 (Ru6), [Ru(MBBtpy)(HOttpy)](PF6)2 (Ru7) complexes were synthesized and characterized by UV/Vis, Fluorescence, FTIR, 1H & 13C NMR, ESI‐mass spectral studies and electrochemical studies. The crystal structure of HOttpy ligand was determined by single crystal X‐ray diffraction. The cyclic voltammograms of Ru(II) complexes exhibit a quasi‐reversible oxidation peak corresponding to RuII/RuIII process. The peak current Ipa and Ipc increases with increase in scan rate. The Ru(II) complexes tested for in vitro antimicrobial activity against four human pathogens and fungus Candida albicans showed good antibacterial and antifungal activity. The binding of Ru(II) complexes with calf thymus DNA was determined by UV/Vis spectroscopy. The cleavage activity of ruthenium(II) complexes studied by gel electrophoresis indicates that these complexes can cleave pUC19 DNA more efficiently when compared to that of control.

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Design, Synthesis and Photodynamic Antimicrobial Activity of Ruthenium Trischelate Diimine Complexes

Cited by 28 publications

References 13 publications

Recent Advances on Octahedral Polypyridyl Ruthenium(II) Complexes as Antimicrobial Agents

Recent Advances on Octahedral Polypyridyl Ruthenium(II) Complexes as Antimicrobial Agents

Encapsulation of a Ru(II) Polypyridyl Complex into Polylactide Nanoparticles for Antimicrobial Photodynamic Therapy

Synthesis, Characterization, Photophysical and Electrochemical Studies of Ruthenium(II) Complexes with 4′‐Substituted Terpyridine Ligands and Their Biological Applications

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