Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors

Zhang, Li; Zhang, Jie; Fang, Hao; Wang, Qiang; Xu, Wenfang

doi:10.1016/j.bmc.2006.09.015

Cited by 27 publications

(21 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The organic extracts were combined, dried over Na 2 SO 4 , and the solvent was evaporated. The residue was purified by silica gel column chromatography [51,52]. Compounds 9, 12, and 16 were prepared according to the method III.…”

Section: Methods IIImentioning

confidence: 99%

Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages

Gürkan¹,

Karabay²,

Büyükbingöl³

et al. 2011

European Journal of Medicinal Chemistry

View full text Add to dashboard Cite

Section: Methods IIImentioning

confidence: 99%

Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages

Gürkan¹,

Karabay²,

Büyükbingöl³

et al. 2011

European Journal of Medicinal Chemistry

View full text Add to dashboard Cite

“…Most of them are designed according to the "combination principles". Consequently, many active fragments with potential pharmaceutical values, such as gallic acid [75] and cinnamic acid [76], are incorporated into trans-4-hydroxy-L-proline backbone to form new integrated structural patterns (10)(11)(12)(13). Some of the resulting compounds, e.g.…”

Section: Mmpis Based On the Pyrrolidine Platformmentioning

confidence: 99%

Recent Advances in the Development of MMPIs and APNIs Based on the Pyrrolidine Platforms

2010

MRMC

View full text Add to dashboard Cite

Pyrrolidine scaffold has been widely used to design a variety of N-heterocyclic derivatives towards various targets. Amongst them, matrix metalloproteins (MMPs) and aminopeptidase N (APN) represent two kinds of important metalloproteinase targets which have been proved to be tightly related to tumor proliferation, invasion, metastasis and angiogenesis. As a result, their respective inhibitors, namely MMP inhibitors (MMPIs) and APN inhibitors (APNIs), have been systematically studied in our group for many years. Recent advances in the elucidation of MMPIs and APNIs based on the pyrrolidine platforms are briefly reviewed in this paper.

show abstract

“…In our previous work, the 4-hydroxy-L-proline has been used to prepare a series of pyrrolidine derivatives as matrix metalloproteinases (MMPs) and aminopeptidase-N (APN) inhibitors [6,7]. We firstly screened all the pyrrolidine derivatives in our compound library including not only the target compounds and intermidates we synthesized before, but also some commercially available compounds.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Preliminary Evaluation of New Pyrrolidine Derivatives as Neuraminidase Inhibitors

Zhang¹,

Xu²,

Liu³

et al. 2008

Self Cite

View full text Add to dashboard Cite

A series of pyrrolidine derivatives were designed and synthesized in good yields starting from commercially available 4-hydroxy-L-proline using a suitable synthetic strategy. And their ability to inhibit neuraminidase was evaluated. These compounds showed potent inhibitory activity against influenza A (H3N2) neuraminidase. Within this series, four compounds, 6e, 9c, 9f and 10e, have the good potency (IC(50)=1.56 approximately 2.40microM) which is compared to the NA inhibitor oseltamivir (IC(50)=1.06microM), and could be used as lead compound in the future.

show abstract

Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors

Cited by 27 publications

References 7 publications

Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages

Synthesis and effects of some novel tetrahydronaphthalene derivatives on proliferation and nitric oxide production in lipopolysaccharide activated Raw 264.7 macrophages

Recent Advances in the Development of MMPIs and APNIs Based on the Pyrrolidine Platforms

Design, Synthesis, and Preliminary Evaluation of New Pyrrolidine Derivatives as Neuraminidase Inhibitors

Contact Info

Product

Resources

About