Design, synthesis, and preliminary<i>in vitro</i>and<i>in vivo</i>pharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents

Sekhar, Kondapalli Venkata Gowri Chandra; Rao, V. S.; Deuther‐Conrad, Winnie; Reddy, Aravalli Satish; Brust, Peter; Kumar, M. Murali Krishna

doi:10.3109/14756366.2010.537658

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…The intermediate ANI-1 was prepared as per the literature reported protocol. 39 Compound ANI-1 on treatment with chloroacetyl chloride in the presence of triethylamine (Et 3 N) as a base at room temperature yielded ANI-2. Confirmation of compound ANI-2 , is by observing a 1 : 3 chloro pattern in mass spectrum. Compound ANI-1 is subjected to an acid amine coupling with 5-nitrofuran-2-carboxylic acid ( 6 ) in the presence of HOBt, EDC·HCl, and DIPEA.…”

Section: Resultsmentioning

confidence: 99%

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Design, synthesis, and anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitrile analogues

Khetmalis,

Shobha,

Nandikolla

et al. 2024

RSC Adv.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitrile analogues

Khetmalis,

Shobha,

Nandikolla

et al. 2024

RSC Adv.

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1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

Madaan

Verma

Kumar

et al. 2015

Archiv der Pharmazie

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The 1,8-naphthyridine group of compounds have gained special attention of researchers on account of their demonstrating a variety of interesting biological activities. A wide range of biological properties establishes them as potent scaffolds in therapeutic and medicinal research. The broad spectrum of activities primarily includes antimicrobial, antiviral, anticancer, anti-inflammatory, and analgesic activities. 1,8-Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer's disease, multiple sclerosis, and depression. In addition, these synthetic derivatives have been found to possess activities such as anti-osteoporotic (α(v)β(3) antagonists), anti-allergic, antimalarial, gastric antisecretory, bronchodilator, anticonvulsant, anti-hypertensive, platelet aggregation inhibition, anti-oxidant, EGFR inhibition, protein kinase inhibition, ionotropic agent, β-3 antagonist, MDR modulator, adenosine receptor agonist, adrenoceptor antagonist, and pesticide activities. In spite of the widespread application of the 1,8-naphythyridine scaffolds, only a limited number of review articles are available till date. In this review, we attempt to compile and discuss the key data available in the literature for the multiple biological activities of 1,8-naphthyridine derivatives, in a chronological manner. This review compilation (with 199 references) may be helpful in understanding the diverse biological properties of 1,8-naphthyridines and provide insights into their mechanism of action. This may direct future research in the synthesis of new derivatives and exploring this scaffold for other possible biological activities.

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Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl]phenyl}thiazoles as atypical antipsychotic agents

et al. 2012

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Design, synthesis, and preliminaryin vitroandin vivopharmacological evaluation of 2-{4-[4-(2,5-disubstituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents

Cited by 6 publications

References 28 publications

Design, synthesis, and anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitrile analogues

Design, synthesis, and anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitrile analogues

1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 4-{4-[2-(4-(2-substitutedquinoxalin-3-yl)piperazin-1-yl)ethyl]phenyl}thiazoles as atypical antipsychotic agents

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