Design, Synthesis, and Preparation of Ultrasound-Responsive Curcumin-Loaded Chitosan Nanocarriers

Zhou, Ying; Li, Shifu; Tan, Weiyan; Wei, Xin; Chen, Yi; Yi, Qingyuan; Pu, Chun; Wang, Jianyi

doi:10.1134/s1070363223010152

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Under ultrasound-free conditions, drug release of curcumin was very slow within 0–48 h, while the release of curcumin was very quick under ultrasound stimulation. The amount of drug releases reached 2.68 μg/mL at the 6 h. These findings suggest that chitosan possesses considerable ultrasound-sensitive nanoparticles, enabling controlled and on-demand drug release …”

Section: Chitosan-based Biomaterials For Drug Delivery Systemmentioning

confidence: 77%

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Budiarso,

Rini,

Tsalsabila

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past decade, smart and functional biomaterials have escalated as one of the most rapidly emerging fields in the life sciences because the performance of biomaterials could be improved by careful consideration of their interaction and response with the living systems. Thus, chitosan could play a crucial role in this frontier field because it possesses many beneficial properties, especially in the biomedical field such as excellent biodegradability, hemostatic properties, antibacterial activity, antioxidant properties, biocompatibility, and low toxicity. Furthermore, chitosan is a smart and versatile biopolymer due to its polycationic nature with reactive functional groups that allow the polymer to form many interesting structures or to be modified in various ways to suit the targeted applications. In this review, we provide an up-to-date development of the versatile structures of chitosan-based smart biomaterials such as nanoparticles, hydrogels, nanofibers, and films, as well as their application in the biomedical field. This review also highlights several strategies to enhance biomaterial performance for fast growing fields in biomedical applications such as drug delivery systems, bone scaffolds, wound healing, and dentistry.

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Section: Chitosan-based Biomaterials For Drug Delivery Systemmentioning

confidence: 77%

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Budiarso,

Rini,

Tsalsabila

et al. 2023

ACS Biomater. Sci. Eng.

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“…The system provided sustained drug release and lower cytotoxicity than using DOX alone. In particular, chitosan, a cationic, naturally derived polysaccharide from chitin, has been an attractive choice in the development of nanogels for the delivery of numerous drugs, such as DOX [ 8 , 9 , 10 , 11 , 12 ], curcumin (CUR) [ 13 , 14 ], 5-fluorouracil [ 15 ], and paclitaxel [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin

Veloso,

Marta,

Rodrigues

et al. 2023

Pharmaceutics

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In this study, multicore-like iron oxide (Fe3O4) and manganese ferrite (MnFe2O4) nanoparticles were synthesized and combined with nanogels based on chitosan and alginate to obtain a multimodal drug delivery system. The nanoparticles exhibited crystalline structures and displayed sizes of 20 ± 3 nm (Fe3O4) and 11 ± 2 nm (MnFe2O4). The Fe3O4 nanoparticles showed a higher saturation magnetization and heating efficiency compared with the MnFe2O4 nanoparticles. Functionalization with citrate and bovine serum albumin was found to improve the stability and modified surface properties. The nanoparticles were encapsulated in nanogels, and provided high drug encapsulation efficiencies (~70%) using doxorubicin as a model drug. The nanogels exhibited sustained drug release, with enhanced release under near-infrared (NIR) laser irradiation and acidic pH. The nanogels containing BSA-functionalized nanoparticles displayed improved sustained drug release at physiological pH, and the release kinetics followed a diffusion-controlled mechanism. These results demonstrate the potential of synthesized nanoparticles and nanogels for controlled drug delivery, offering opportunities for targeted and on-demand release in biomedical applications.

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Fabrication of polycaprolactone-chitosan/curcumin polymer composite fibers and evaluation of their in vitro release kinetic behavior and antibacterial-antifungal activity

Ciftci,

Özarslan

2023

J Sol-Gel Sci Technol

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Design, Synthesis, and Preparation of Ultrasound-Responsive Curcumin-Loaded Chitosan Nanocarriers

Cited by 3 publications

References 32 publications

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Chitosan/Alginate Nanogels Containing Multicore Magnetic Nanoparticles for Delivery of Doxorubicin

Fabrication of polycaprolactone-chitosan/curcumin polymer composite fibers and evaluation of their in vitro release kinetic behavior and antibacterial-antifungal activity

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