Design, Synthesis, and Self‐Assembly of Janus Bottlebrush Polymers

The future of electronic materials is…degradable!

“…Poly imine or poly imide with different substrates like fish colloid, siloxane, and anhydrides were found to be thermally stable, and some of them were found to be water disintegrable, so, overall, they show excellent degradability, biocompatibility, flexibility, recyclability, and extensibility. 35–38 Naphthalene diimide based polymers were found to be active and degradable at pH lower than 7; the acidic conditions allow an efficient charge transport through its extended π-conjugation. 25 The breakdown of imide groups after degradation leads to acids and amides; also, the imines yield either aldehyde or ketone with amine (Fig.…”

“…37 A fluorinated version of the same material represents a fully degradable substrate in ethanol. 35 A simpler polyamide network instead has been obtained from aromatic dialdehydes and diamines and applied as a recyclable and flexible membrane. 36…”

Molecular Bottlebrushes as Emerging Nanocarriers: Material Design and Biomedical Application

“…With the development of synthetic chemistry, a variety of efficient and controllable synthetic techniques, such as atom transfer radical polymerization (ATRP), − reversible addition–fragmentation chain transfer (RAFT) polymerization, − and ring-opening metathesis polymerization (ROMP) − have been discovered, making it possible to obtain MBBs with tunable sizes, morphologies, and functions for many practical applications. There have been a few existing reviews on MBBs, which primarily concentrate on aspects such as synthesis, self-assembly behavior, or general discussions on applications. − However, they do not delve into great detail regarding the potential use of MBBs as nanocarriers for biomedical purposes. Recognizing this gap in the literature, we explore and discuss this specific aspect in our Review.…”

Self-Aggregation in Aqueous Media of Amphiphilic Diblock and Random Block Copolymers Composed of Monomers with Long Side Chains

“…Inspired by the well-defined macromolecular architecture, shape, and functionality of a complex group of biomolecules known as proteoglycans, a type of bottlebrush-like biopolymers, − synthetic bottlebrush polymers are a special class of branched or comb/graft polymers consisting of flexible polymeric side chains densely grafted to a linear backbone. − These structures, also known as molecular brushes or cylindrical polymer brushes, have various architectures depending on the orientation of their backbone and side chains, as well as their grafting densities . The advent of ring-opening metathesis polymerization (ROMP), and particularly controlled/living radical polymerization techniques, including atom transfer radical polymerization (ATRP), reversible addition-fragmentation chain transfer (RAFT), and nitroxide-mediated radical polymerization (NMP), opened to the design of bottlebrush polymers with a great variety of complex structures and well-regulated dimensions. − According to how the side chains of the bottlebrush polymers are formed, there are three main strategies for the preparation of bottlebrush polymers, the “grafting-through” (polymerization of macromonomers), “grafting-to” (attachment of pre-formed side chains to a backbone), and “grafting-from” (synthesis of side chains from a backbone polyinitiator). − ,− Depending on the synthetic route utilized, bottlebrushes polymers with various architectures and topologies can be obtained, including linear, branched, cyclic brushes with block copolymer backbones, random (heterografted) bottlebrush block copolymers, core–shell, brush-on-brush, Janus types, etc. ,− …”