Design, Synthesis and Spectroscopic Characterizations of Medicinal Hydrazide Derivatives and Metal Complexes of Malonic Ester

Abstract

Background: A new series of malonic acid-based hydrazide derivatives (BPMPDH, 2HPMPDH, 3HPMPDH, 4HPMPDH, DMPDH) are successfully synthesized by the reaction of malonic ester hydrazide with various substituted aldehydes like salicylaldehyde, benzaldehyde, 4-hydroxy benzaldehyde, 3-hydroxy benzaldehyde and formaldehyde) Methods: metal complexes of prepared hydrazide derivatives were prepared using metals like Cu+2, Zn+2 and Ni+2 via a mild, efficient and convenient method. Newly synthesized compounds were characterized by IR, NMR (1H & 13C), UV/VIS and mass spectrometry. The presence of –C=N- peak at 1600-1700 cm-1 with the absence of NH2 peak at 3500 cm-1 in FTIR spectra. In 1HNMR peak at, 11.00-13.00 ppm for –OH protons and 7.00-9.50 ppm for –NH verified the synthesis of new hydrazide derivatives. The presence of a C-OH sharp peak at 180-190 ppm, a C=O peak at 160-170 ppm and a C=N peak at 140-150 ppm confirmed synthesis. In mass spectra, the molecular ion peaks at 308 m/z, 340 m/z and 156 m/z confirmed synthesis. Synthesized compounds have also been analyzed for their antioxidant, antibacterial, antifungal, chymotrypsin and tyrosinase inhibition activities Result and Conclusion: The results revealed that the 2HPMPDH, 3HPMPDH, 4HPMPDH and their Cu+2 and Zn+2 metal complexes showed more successful inhibition against standard drugs, based on structure activity relationship.

Tamarindus indica seed polysaccharide-copper nanocomposite: An innovative solution for green environment and antimicrobial studies

“…In conclusion the synthesis of the composite material involving Cu-NPs and TSP offers a synergistic approach to harness the unique properties of both components. The combination of Cu-NPs and TSP may lead to composite materials with enhanced functionalities, biocompatibility, and potential applications in various fields such as biomedicine and environmental science [ [23] , [24] , [25] ]. This work aimed to extract TSP from Tamarindus indica seeds and characterized its physical and chemical properties.…”

Evaluation of bioactivity and antibacterial properties of Ti6Al4V-based green biocomposite implant encompassing TiO2 nanotube arrays and garlic extract

“…Various materials ranging from chemical antibiotics to synthesized metal complexes, metal ions, and natural drug compounds have been utilized for the production of antimicrobial agents [ [34] , [35] , [36] , [37] , [38] ]. The use of natural medicinal compounds constitutes a comprehensive approach aimed at operating within the realm of natural bone therapeutics.…”

Synthesis and Structure of a Coordination Polymer of Ni(II) with 2-(4-Bromophenoxy)acetohydrazide

“…The presence of electron-donating groups and transition metals was observed to enhance the biological activities, as demonstrated by the formation of complexes of malonic acid-based hydrazide derivatives with copper(II) and zinc(II) metals. These compounds were evaluated for their antioxidant, antibacterial, antifungal, chymotrypsin, and tyrosinase inhibition activities, exhibiting more effective inhibitory effects compared to standard drugs [8]. The synthesized Ni(II) chloride complex with the 2-(p-tolylamino)acetohydrazide ligand was investigated, demonstrating efficacy in vitro for the treatment of Eobania vermiculata [9].…”