Design, synthesis, anti-TMV activity, and preliminary mechanism of cinnamic acid derivatives containing dithioacetal moiety

Wang, Yanju; He, Fangcheng; Wu, Sikai; Luo, Yuqin; Wu, Rong; Hu, Deyu; Song, Baoan

doi:10.1016/j.pestbp.2020.01.002

Cited by 18 publications

(15 citation statements)

References 36 publications

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“…Treatment of TMV particles with 34b caused serious damage and fracture. Molecular docking results showed that 34b bonded excellently with amino acid residues GLN34, THR37, ARG90, and ARG46 of TMV coat protein via hydrogen bonds [27].…”

Section: Sodium Hypochloritementioning

confidence: 99%

“…Wang et al evaluated anti-Tobacco mosaic virus (TMV) activities of synthesized cinnamic acid derivatives containing dithioacetal moieties. Only 34a and 34b ( Figure 7) displayed curative activities of 82.6% and 83.5%, respectively which were significant when compared to ribavirin (70.3%) and xiangcaoliusuobingmi (71.7%), used as the control [27]. Wang et al evaluated anti-Tobacco mosaic virus (TMV) activities of synthesized cinnamic acid derivatives containing dithioacetal moieties.…”

Section: Sodium Hypochloritementioning

confidence: 99%

“…In vitro cytotoxicity of the hybrids on a human liver hepatocellular carcinoma cell line (HepG2) depended on Figure 7. Cinnamic acid derivatives with dithioacetal moieties (34a and 34b) [27].…”

Section: Cinnamic Acid Derivatives With Anticancer Activitymentioning

confidence: 99%

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Cinnamic Acid Derivatives and Their Biological Efficacy

Ruwizhi

Aderibigbe

2020

IJMS

279

134

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The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological efficacy of the synthesized cinnamic acid derivatives. Some of the derivatives have been reported to be more effective when compared to the standard drugs used to treat chronic or infectious diseases in vitro, thus making them very promising therapeutic agents. Compound 20 displayed potent anti-TB activity, compound 27 exhibited significant antibacterial activity on S. aureus strain of bacteria and compounds with potent antimalarial activity are 35a, 35g, 35i, 36i, and 36b. Furthermore, compounds 43d, 44o, 55g–55p, 59e, 59g displayed potent anticancer activity and compounds 86f–h were active against both hAChE and hBuChE. This review will expound on the recent advances on cinnamic acid derivatives and their biological efficacy.

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Section: Sodium Hypochloritementioning

confidence: 99%

Section: Sodium Hypochloritementioning

confidence: 99%

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Cinnamic Acid Derivatives and Their Biological Efficacy

Ruwizhi

Aderibigbe

2020

IJMS

279

134

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“…FA is also reported as a precursor for the chemical synthesis of derivatives containing a dithioacetal moiety. A series of such compounds has been tested for their activity against TMV, and the most successful hit achieved higher antiviral activity than commercial virucidal ribavirin (62.5% curative, 61.8% protective and 83.5% inactivating activity at a concentration of 500 µg/ml) (114).…”

Section: Fa Derivatives As Antiviral Agents Chemically Synthesized De...mentioning

confidence: 99%

Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties

2022

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Plant biomass is a magnificent renewable resource for phytochemicals that carry bioactive properties. Ferulic acid (FA) is a hydroxycinnamic acid that is found widespread in plant cell walls, mainly esterified to polysaccharides. It is well known of its strong antioxidant activity, together with numerous properties, such as antimicrobial, anti-inflammatory and neuroprotective effects. This review article provides insights into the potential for valorization of FA as a potent antiviral agent. Its pharmacokinetic properties (absorption, metabolism, distribution and excretion) and the proposed mechanisms that are purported to provide antiviral activity are presented. Novel strategies on extraction and derivatization routes, for enhancing even further the antiviral activity of FA and potentially favor its metabolism, distribution and residence time in the human body, are discussed. These routes may lead to novel high-added value biorefinery pathways to utilize plant biomass toward the production of nutraceuticals as functional foods with attractive bioactive properties, such as enhancing immunity toward viral infections.

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“…Biological tests showed that most of the title compounds exhibited significant anti-TMV biological activities, particularly compound 118 (Figure 36) showed good inactivation activity against TMV, with an EC 50 value of 54.2 mg/L, which was superior to that of Ribavirin. Meanwhile, a series of cinnamic acid derivatives containing a dithioacetal moiety were synthesized and their anti-plant virus activity against TMV was evaluated by Wang and coworkers [120]. Biological tests revealed that compound 119 (Figure 36), especially at 500 mg/L concentration, had excellent activity against TMV, and its curative, protection, and inactivation activities were 62.5%, 61.8%, and 83.5%, respectively, which were significantly superior to those of Ribavirin and comparable to those of Ningnanmycin.…”

Section: Antiviral Activitymentioning

confidence: 99%

Recent achievements on the agricultural applications of thioether derivatives: A 2010–2020 decade in review

Yang²,

Wang

et al. 2021

Journal of Heterocyclic Chem

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Thioether derivatives, an important synthetic strategy in drug discovery, are acquiring more importance in plant protection field in recent years because of their broad spectrum of agricultural activities, such as antifungal, antibacterial, insecticidal, acaricidal, nematocidal, antiviral, herbicidal, and plant growthregulating activity. Thioethers and their analogues have been an area of great interest in recent years. This review summarizes the structure and agricultural activities of the thioether derivatives as reported in the literature that mainly covers the past 10 years from 2010 to 2020 as well as may contribute to a better understanding of thioether derivatives as efficient agricultural agents and provide some ideas on the development of novel pesticides.

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Design, synthesis, anti-TMV activity, and preliminary mechanism of cinnamic acid derivatives containing dithioacetal moiety

Cited by 18 publications

References 36 publications

Cinnamic Acid Derivatives and Their Biological Efficacy

Cinnamic Acid Derivatives and Their Biological Efficacy

Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties

Recent achievements on the agricultural applications of thioether derivatives: A 2010–2020 decade in review

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