2024
DOI: 10.1002/slct.202304791
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Design, Synthesis, Antibacterial and Antitubercular Studies of Some New Benzimidazoles. A Combined Experimental and Computational Approach

Tushar Ranjan Mohapatra,
Swastika Ganguly

Abstract: A novel series of seventeen 2‐(4‐chlorophenyl)‐1H‐benzo[d]imidazole‐N‐aryl acetamides derivatives 3(a–q) were synthesized by nucleophilic substitution of 2‐chloro‐N‐(aryl)‐acetamides 2(a–q) with 2‐(4‐chlorophenyl)‐1H‐benzo[d]imidazole (1) in N,N‐Dimethylformamide. The literature indicates that the primary compound, 2‐(4‐chlorophenyl)‐1H‐benzo[d]imidazole (1), not only serves as a synthetic precursor but also exhibit anthelmintic, antiviral, and antifungal activities. The synthesized compounds were estimated fo… Show more

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