2023
DOI: 10.1002/slct.202300286
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Design, Synthesis, Characterization and Biological Activities of Novel S‐(Acyloxy)butyl‐N,N‐Diethyldithiocarbamate Compounds

Abstract: In this study, S‐(Acyloxy)butyl‐N,N‐Diethyldithiocarbamate compounds (P1‐P7) were synthesized by s‐alkylation of N,N‐diethyldithiocarbamate sodium trihydrate with 4‐chlorobutylcarboxylates. P1–P7 were characterized by full infrared, NMR spectroscopy and elemental analyses. Additionally, the impacts of these compounds were investigated on some metabolic enzymes and then compared to the reference compounds. It was observed that the DEDTCA esters generally had lower IC50 and Ki values. Among them, P4 and P6 molec… Show more

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Cited by 6 publications
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