III-Nitride Metal-Oxide-Semiconductor Heterojunction (MOSH) structure consists of a thin dielectric layer deposited on top of a semiconductor heterostructure with a 2D electron gas at the heterojunction interface. MOSH structures are the key components for high-power low-loss, fast RF switches. The paper discusses two types of high-power switches using III-Nitride MOSH structures. The first type uses the MOSH structure as the gate region of an AlGaN/GaN HFET. The second type uses MOSH structure as a switching capacitor. In the 2GHz - 10 GHz frequency range, switching powers from 20 to 60 W/mm have been achieved with the insertion loss below 1 dB.