Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug

Kaliyamoorthi, Kiruthiga; Pillai, Archana Sumohan; Alexander, Aleyamma; Ramasamy, Sivaraj; Arivarasu, Anitha; Enoch, Israel V.M.V.

doi:10.1007/s10853-020-05466-w

Cited by 29 publications

(7 citation statements)

References 27 publications

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“…These differences may be mainly due to the interaction between the layers of LDH and interlayer CPT (e. g., hydrogen bonding action) [39,40] . Meanwhile, the N1s signal appeared in the ZnAl‐Eu‐CPT and the binding energies of N 1s at 398.92 and 400.50 eV are attributed to quinoline N and pyrrole N of CPT, respectively, [41‐43] and binding energy at 406.78 eV is due to NO 3 − [44,45] . The binding energy at 284.82 eV of C1s is related to the C−C, C−N, and C=N bonds [43] .…”

Section: Resultsmentioning

confidence: 99%

Eu‐doped ZnAl‐LDH as a Fluorescent Labeling Carrier for the Delivery and Controlled Release of Camptothecin

Qiu

et al. 2022

ChemistrySelect

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Europium doped Zinc‐aluminum layered double hydroxide (Eu‐doped ZnAl‐LDH) as a fluorescent labeling carrier for the delivery and controlled release of camptothecin (CPT) has been studied. X‐ray diffraction (XRD) patterns showed that the basal spacing of the Eu‐doped ZnAl‐LDH intercalated with CPT (2.27 nm) was larger than that of the initial Eu‐doped ZnAl‐LDH (0.88 nm), indicating the successful intercalation of CPT into the Eu‐doped ZnAl‐LDH carrier. X‐ray photoelectron spectroscopy (XPS) suggested that some Eu(III) were reduced to Eu(II) after the intercalation of CPT into the Eu‐doped ZnAl‐LDH. The release of the CPT from drug carrier was carried out in a simulated medium. It was found that the cumulative concentration of the released CPT was exponential with releasing time, and well conformed to the exponential equation: C=A‐Bexp(‐kt). It took 720 minutes (min) for the complete release of CPT from drug carrier. Fluorescent analyses revealed that the fluorescence attributed to the drug delivery system changed from red, blue‐green, to blue emission during delivery and release of CPT, which may be a favorable signal for “detecting” the delivery and release of CPT. Thus, the present Eu‐doped ZnAl‐LDH may be a feasible drug carrier with fluorescent labeling function.

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Section: Resultsmentioning

confidence: 99%

Eu‐doped ZnAl‐LDH as a Fluorescent Labeling Carrier for the Delivery and Controlled Release of Camptothecin

Qiu

et al. 2022

ChemistrySelect

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“…In another drug delivery work, Enoch and coworkers designed a drug delivery system utilizing host–guest interaction with β-CD attached poly(ethylene) glycol-coated magnetic nanoparticles and the chemotherapeutic agent camptothecin (CPT) [ 47 ]. Firstly, one of the lanthanide elements’ erbium-doped nanoparticles was synthesized and they were coated with β-CD attached poly(ethylene) glycol-folate conjugate synthesized earlier.…”

Section: Self-assembly Of Cyclodextrin-coated Nanoparticlesmentioning

confidence: 99%

Self-Assembly of Cyclodextrin-Coated Nanoparticles:Fabrication of Functional Nanostructures for Sensing and Delivery

et al. 2023

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In recent years, the bottom-up approach has emerged as a powerful tool in the fabrication of functional nanomaterials through the self-assembly of nanoscale building blocks. The cues embedded at the molecular level provide a handle to control and direct the assembly of nano-objects to construct higher-order structures. Molecular recognition among the building blocks can assist their precise positioning in a predetermined manner to yield nano- and microstructures that may be difficult to obtain otherwise. A well-orchestrated combination of top-down fabrication and directed self-assembly-based bottom-up approach enables the realization of functional nanomaterial-based devices. Among the various available molecular recognition-based “host–guest” combinations, cyclodextrin-mediated interactions possess an attractive attribute that the interaction is driven in aqueous environments, such as in biological systems. Over the past decade, cyclodextrin-based specific host–guest interactions have been exploited to design and construct structural and functional nanomaterials based on cyclodextrin-coated metal nanoparticles. The focus of this review is to highlight recent advances in the self-assembly of cyclodextrin-coated metal nanoparticles driven by the specific host–guest interaction.

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“…The stealthy behavior of coated MNPs can combat the liver phagocytosis enabling to increase in the half-life of the formulation. Recently, β-cyclodextrin-PEG-FA coated camptothecin-loaded MNPs exhibited enhanced antitumor activity [171] . Other routes such as intraperitoneal, intramuscular, retroorbital, and subcutaneous are also used for the administration of MNPs.…”

Section: Pharmacokinetic and Biodistribution Of Hp-mnpsmentioning

confidence: 99%

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Kush

Kumar

Singh

et al. 2021

Asian Journal of Pharmaceutical Sciences

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This review covers extensively the synthesis & surface modification, characterization, and application of magnetic nanoparticles. For biomedical applications, consideration should be given to factors such as design strategies, the synthesis process, coating, and surface passivation. The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration. Special insights have been provided on biodistribution, pharmacokinetics, and toxicity in a living system, which is imperative for their wider application in biology. These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging, for example, MRI-CT, MRI-PET. Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body. Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction, heat conduction, imaging, and magnetism. Surely, this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.

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Designed poly(ethylene glycol) conjugate-erbium-doped magnetic nanoparticle hybrid carrier: enhanced activity of anticancer drug

Cited by 29 publications

References 27 publications

Eu‐doped ZnAl‐LDH as a Fluorescent Labeling Carrier for the Delivery and Controlled Release of Camptothecin

Eu‐doped ZnAl‐LDH as a Fluorescent Labeling Carrier for the Delivery and Controlled Release of Camptothecin

Self-Assembly of Cyclodextrin-Coated Nanoparticles:Fabrication of Functional Nanostructures for Sensing and Delivery

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

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