Introduction: UNESCO defines Open Educational Resources (OER) as freely accessible and adaptable educational materials, whose integration in education, especially in post-pandemic times and in the digital era, has been limited, despite the efforts of institutions such as the Facultad de Estudios Superiores Zaragoza to promote their use in hybrid and flexible teaching modalities. This study analyzes the transformation of higher education in the context of the COVID-19 pandemic, focusing on the integration and impact of Open Educational Resources (OER) and Information and Communication Technologies (ICT). Methods: A literature review and analysis of current educational practices in universities was conducted, with special attention to the adoption of OER and the use of hybrid and digital teaching methodologies. Results: The results indicate that, despite the accessibility and adaptability of OER, their adoption in university education has not been extensive, mainly attributed to lack of knowledge about their use and potential. The pandemic has accelerated the need to adapt pedagogical strategies, highlighting the importance of interaction and collaboration in learning. Maker pedagogy and 3D printing are identified as valuable tools to improve understanding and practical skills, especially in the health sciences. Conclusion: The study concludes that post-pandemic education requires an adaptive, interactive and technologically integrated approach, promoting continuous learning and adaptation to changing cultural and cognitive practices. It underscores the need to democratize design and manufacturing technologies and to foster collaborative and participatory learning communities through OER.