Designing a miniaturized photonic crystal based optofluidic biolaser for lab-on-a-chip biosensing applications

Mozaffari, Mohammad Hazhir; Ebnali-Heidari, Majid; Abaeiani, Gholamreza; Moravvej-Farshi, Mohammad Kazem

doi:10.1016/j.orgel.2017.12.040

Cited by 24 publications

(6 citation statements)

References 39 publications

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“…[ 69 ] Vibrational strong coupling must be reached with fewer molecules to achieve single‐photon IR sources, which could be realized with miniaturized photonic cavities. [ 70,71 ]…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

“…[69] Vibrational strong coupling must be reached with fewer molecules to achieve single-photon IR sources, which could be realized with miniaturized photonic cavities. [70,71] Overall, MVPs is an emerging field with great potential and understanding this new field could impact the development of quantum technology for use at room temperature.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

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Molecular Vibrational Polaritons Towards Quantum Technologies

Yang

Xiang

2022

Adv Quantum Tech

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Molecular vibrational polaritons (MVPs)-a hybrid molecular-photon quasiparticle-and the development of a proof-of-principle quantum technology platform are discussed to simulate coherence transfer, for use at room temperature. It is shown that MVPs can form qubits, coherence, and have nonlinear interactions, all at room temperature. Some new insights, such as polaritonic nonlinearity dependence on macroscopic properties including cavity thickness and molecular concentrations are also uncovered. It is hoped that these advances can stimulate more research in developing this system into a quantum technology platform free from the constraints imposed by the requirement of cryogenic conditions.

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“…[ 69 ] Vibrational strong coupling must be reached with fewer molecules to achieve single‐photon IR sources, which could be realized with miniaturized photonic cavities. [ 70,71 ]…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Molecular Vibrational Polaritons Towards Quantum Technologies

Yang

Xiang

2022

Adv Quantum Tech

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“…Many efforts have been made to achieve biological microlasers by using various cavity structures such as Fabry-Pérot (FP) [12,13], distributed feedback (DFB) [14], whispering gallery mode (WGM) [15][16][17], photonic crystals [18,19] and random cavities [20][21][22]. The conventional architectures such as FP, DFB, WGM and photonic crystal-based cavities have shown their great advantages in making high quality (Q) factor miniaturized biolasers.…”

Section: Introductionmentioning

confidence: 99%

High quality factor, protein-based microlasers from self-assembled microcracks

Nguyen

Hong

Thin

et al. 2021

J. Phys. D: Appl. Phys.

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In the last decade, microlasers with biological origin have shown their great potential in biosensing and bioimaging. Several micro-structures have been developed for high quality (Q) factor biolasers including Fabry–Pérot, distributed feedback and whispering gallery mode cavities. However, the fabrication of these lasers is generally complicated and their operation is strongly affected by cavity defects. In this work, we demonstrate random protein-based microlasers fabricated by a simple one-step self-assembled method. The lasing can be achieved from microcracks with random structures. The lasing threshold is around 14 mJ cm−2 and the quality factor of lasing modes can be up to 3 × 10 3 which are comparable with other conventional biolasers. Our work opens a new possibility for the fabrication of high Q factor microlasers from biocompatible materials, with great potential for biosensing and biomedical applications.

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“…Since photonic crystal (PhC) cavities besides their beneficial properties, provide a facility for incorporation of analytes to the fluidic gain medium, they are a good candidate for exploiting in optofluidic biolasers. In our previous works [5,6], we designed two optofluidic biolasers based on the PhC structures for lab-on-a-chip biosensing applications. In view of those design procedures, here we theoretically propose a simple and more sensitive PhC-based optofluidic biolaser whereas a feasible proposal for intensity-based biosensing via this extensible device is presented.…”

mentioning

confidence: 99%

“…The innermost hole is infiltrated by Rhodamine 6G organic dye solution dissolved in water at the concentration of 4 × 10 −4 g ml −1 and acts as the optofluidic biolaser active region. These geometrical parameters were initially attained from our previous experiences on PhC slabs [5][6][7][8] and then accurately optimized by the particle swarm optimization method. The proposed structure pumped via a TE polarized Nd:YAG laser with 6 ns pulses of wavelength λ = 532 nm, located in close proximity of the slab surface which evanescently coupled to the PhC structure.…”

mentioning

confidence: 99%

A proposal for ultra-sensitive intensity-based biosensing via photonic crystal optofluidic biolaser

2019

Self Cite

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A highly sensitive photonic crystal-based optofluidic biolaser and a feasible proposal for labon-a-chip biosensing by this extensible device are theoretically demonstrated. The 3D finitedifference-time-domain simulations indicate that the proposed device can potentially be used in biosensing applications. The results illustrate the intensity sensitivity of 1.45 × 10 5 %/RIU for an HIV-1 virion. Moreover, the dependencies of the lasing characteristics such as threshold power and power conversion efficiency on the presence of bioparticles inside the dye-filled active medium are investigated.

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Designing a miniaturized photonic crystal based optofluidic biolaser for lab-on-a-chip biosensing applications

Cited by 24 publications

References 39 publications

Molecular Vibrational Polaritons Towards Quantum Technologies

Molecular Vibrational Polaritons Towards Quantum Technologies

High quality factor, protein-based microlasers from self-assembled microcracks

A proposal for ultra-sensitive intensity-based biosensing via photonic crystal optofluidic biolaser

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