Designing a ridge filter based on a mouse foot skin reaction to spread out Bragg-peaks for carbon-ion radiotherapy

Uzawa, Akiko; Andō, Kōichi; Kase, Yuki; Hirayama, Ryoichi; Matsumoto, Yoshitaka; Matsufuji, Naruhiro; Koike, Sachiko; Kobashi, Gén

doi:10.1016/j.radonc.2015.04.007

Cited by 10 publications

(11 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study ( 153 ) by evaluating the therapeutic gain of carbon-ion fractionation using intestinal crypt survival and tumor growth delay (TGD) assays, the values of the α and β terms for the mouse fibrosarcoma (NFSa) tumor are close to those reported by Ando et al ( 148 ), while those for normal tissues are different (Figure 9 ). In addition, the LET-dependent increase (e.g., slope of the regression line) of the α term for NFSa is similar to that for human salivary gland tumor cells ( 148 , 154 ). LET-dependent increase of α terms for crypt is greater than that for the early skin reaction after daily fractionated doses to leg skin ( 148 ), whereas it is similar to that for the late skin reaction after 4-h interval fractionations to foot skin ( 154 ).…”

Section: Dose Fractionation With Charged Particlesmentioning

confidence: 56%

Effects of Charged Particles on Human Tumor Cells

et al. 2016

View full text Add to dashboard Cite

The use of charged particle therapy in cancer treatment is growing rapidly, in large part because the exquisite dose localization of charged particles allows for higher radiation doses to be given to tumor tissue while normal tissues are exposed to lower doses and decreased volumes of normal tissues are irradiated. In addition, charged particles heavier than protons have substantial potential clinical advantages because of their additional biological effects, including greater cell killing effectiveness, decreased radiation resistance of hypoxic cells in tumors, and reduced cell cycle dependence of radiation response. These biological advantages depend on many factors, such as endpoint, cell or tissue type, dose, dose rate or fractionation, charged particle type and energy, and oxygen concentration. This review summarizes the unique biological advantages of charged particle therapy and highlights recent research and areas of particular research needs, such as quantification of relative biological effectiveness (RBE) for various tumor types and radiation qualities, role of genetic background of tumor cells in determining response to charged particles, sensitivity of cancer stem-like cells to charged particles, role of charged particles in tumors with hypoxic fractions, and importance of fractionation, including use of hypofractionation, with charged particles.

show abstract

Section: Dose Fractionation With Charged Particlesmentioning

confidence: 56%

Effects of Charged Particles on Human Tumor Cells

et al. 2016

View full text Add to dashboard Cite

show abstract

“…They were raised under specific pathogen-free conditions prior to irradiation. Right hind legs were locally irradiated either ~7 days after transplantation of NFSa fibrosarcoma cells or ~5 days after hair removal by applying a depilatory [4, 11]. For foot skin reaction, no pretreatment was applied prior to irradiation [12].…”

Section: Methodsmentioning

confidence: 99%

“…It should be noted that a local effect model [3] is being used to design the SOBP in Germany and Italy. A new ridge filter was recently designed based on mouse skin reaction, and it was found that the physical dose distribution required to uniformly cause a given skin reaction score was the same as that required to produce 10% cell kill of HSG cells [4, 5]. The dose range used for the 10% cell kill is ~6 Gy, whereas that for skin reaction is almost 10 times larger, i.e.…”

Section: Introductionmentioning

confidence: 99%

Dependence and independence of survival parameters on linear energy transfer in cells and tissues

Andō¹,

Goodhead²

2016

Journal of Radiation Research

Self Cite

View full text Add to dashboard Cite

Carbon-ion radiotherapy has been used to treat more than 9000 cancer patients in the world since 1994. Spreading of the Bragg peak is necessary for carbon-ion radiotherapy, and is designed based on the linear–quadratic model that is commonly used for photon therapy. Our recent analysis using in vitro cell kills and in vivo mouse tissue reaction indicates that radiation quality affects mainly the alpha terms, but much less the beta terms, which raises the question of whether this is true in other biological systems. Survival parameters alpha and beta for 45 in vitro mammalian cell lines were obtained by colony formation after irradiation with carbon ions, fast neutrons and X-rays. Relationships between survival parameters and linear energy transfer (LET) below 100 keV/μm were obtained for 4 mammalian cell lines. Mouse skin reaction and tumor growth delay were measured after fractionated irradiation. The Fe-plot provided survival parameters of the tissue reactions. A clear separation between X-rays and high-LET radiation was observed for alpha values, but not for beta values. Alpha values/terms increased with increasing LET in any cells and tissues studied, while beta did not show a systematic change. We have found a puzzle or contradiction in common interpretations of the linear-quadratic model that causes us to question whether the model is appropriate for interpreting biological effectiveness of high-LET radiation up to 500 keV/μm, probably because of inconsistency in the concept of damage interaction. A repair saturation model proposed here was good enough to fit cell kill efficiency by radiation of wide-ranged LET. A model incorporating damage complexity and repair saturation would be suitable for heavy-ion radiotherapy.

show abstract

“…Also the neutron RBE refers to early skin and tumor reactions rather than late effects . The absorbed dose profile in the mixed‐beam model has been recently recalculated using mouse skin reddening as an endpoint and an almost identical profile has been found . As a further difference, the RBE depth profiles have not been adjusted when the dose per fraction was escalated.…”

Section: Review Of Radiobiological Issues and Clinical Trialsmentioning

confidence: 99%

“…[52][53][54][55] The absorbed dose profile in the mixed-beam model has been recently recalculated using mouse skin reddening as an endpoint and an almost identical profile has been found. 56,57 As a further difference, the RBE depth profiles have not been adjusted when the dose per fraction was escalated. This is due to the realization of the SOBP by hardware components in the beam line and this approach is considered as an approximation.…”

Section: B1 Mixed-beam Modelmentioning

confidence: 99%

Radiobiological issues in prospective carbon ion therapy trials

Fossati

Matsufuji²,

Kamada³

et al. 2018

Medical Physics

Self Cite

View full text Add to dashboard Cite

Carbon ion radiotherapy (CIRT) is developing toward a versatile tool in radiotherapy; however, the increased relative biological effectiveness (RBE) of carbon ions in tumors and normal tissues with respect to photon irradiation has to be considered by mathematical models in treatment planning. As a consequence, dose prescription and definition of dose constraints are performed in terms of RBE weighted rather than absorbed dose. The RBE is a complex quantity, which depends on physical variables, such as dose and beam quality as well as on normal tissue‐ or tumor‐specific factors. At present, three RBE models are employed in CIRT: (a) the mixed‐beam model, (b) the Microdosimetric Kinetic Model (MKM), and (c) the local effect model. While the LEM is used in Europe, the other two models are employed in Japan, and unfortunately, the concepts of how the nominal RBE‐weighted dose is determined and prescribed differ significantly between the European and Japanese centers complicating the comparison, transfer, and reproduction of clinical results. This has severe impact on the way treatments should be prescribed, recorded, and reported. This contribution reviews the concept of the clinical application of the different RBE models and the ongoing clinical CIRT trials in Japan and Europe. Limitations of the RBE models and the resulting radiobiological issues in clinical CIRT trials are discussed in the context of current clinical evidence and future challenges.

show abstract

Designing a ridge filter based on a mouse foot skin reaction to spread out Bragg-peaks for carbon-ion radiotherapy

Cited by 10 publications

References 20 publications

Effects of Charged Particles on Human Tumor Cells

Effects of Charged Particles on Human Tumor Cells

Dependence and independence of survival parameters on linear energy transfer in cells and tissues

Radiobiological issues in prospective carbon ion therapy trials

Contact Info

Product

Resources

About