Designing an ultra-sensitive aptasensor based on an AgNPs/thiol-GQD nanocomposite for TNT detection at femtomolar levels using the electrochemical oxidation of Rutin as a redox probe

Shahdost-fard, Faezeh; Roushani, Mahmoud

doi:10.1016/j.bios.2016.09.048

Cited by 91 publications

(27 citation statements)

References 43 publications

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“…Only one electrochemical aptasensor has been reported to date involving the use of GQDs. Shahdost-fard and Roushani [59] developed a label-free aptasensor for the detection of 2,4,6-Trinitrotoluen (TNT) by immobilizing an amino-modified aptamer (NH 2 -Ap) onto a GCE modified with an AgNPs/thiol-GQD nanocomposite. It is important to note that the same group used this nanocomposite to develop immunosensing platforms [56].…”

Section: Gqds and Cds In Electrochemical Biosensingmentioning

confidence: 99%

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Carbon Dots and Graphene Quantum Dots in Electrochemical Biosensing

2019

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Graphene quantum dots (GQDs) and carbon dots (CDs) are among the latest research frontiers in carbon-based nanomaterials. They provide interesting attributes to current electrochemical biosensing due to their intrinsic low toxicity, high solubility in many solvents, excellent electronic properties, robust chemical inertness, large specific surface area, abundant edge sites for functionalization, great biocompatibility, low cost, and versatility, as well as their ability for modification with attractive surface chemistries and other modifiers/nanomaterials. In this review article, the use of GQDs and CDs as signal tags or electrode surface modifiers to develop electrochemical biosensing strategies is critically discussed through the consideration of representative approaches reported in the last five years. The advantages and disadvantages arising from the use of GQDs and CDs in this context are outlined together with the still required work to fulfil the characteristics needed to achieve suitable electrochemical enzymatic and affinity biosensors with applications in the real world.

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Section: Gqds and Cds In Electrochemical Biosensingmentioning

confidence: 99%

“…Label-free aptasensor developed for the determination of TNT by immobilizing the NH 2 -Ap onto an AgNPs/thiol-GQD/GCE and performing the DPV detection in the presence of RU. Reprinted with permission from [59]. Copyright Elsevier, 2017.…”

Section: Figurementioning

confidence: 99%

Carbon Dots and Graphene Quantum Dots in Electrochemical Biosensing

2019

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“…), Silver nanoparticles (AgNPs) are subject to new engineering techniques with highly novel resulting morphologies and traits. Such NPs have several advantages, making it easier to pass electrons more effectively and to accommodate more active sites on their surface [107,108]. Nevertheless, the use of metallic nanoparticles alone is not adequate for high sensitive detection, which inevitably involves more comprehensive methods.…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Electrochemical biosensors: perspective on functional nanomaterials for on-site analysis

2020

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Background: The electrochemical biosensor is one of the typical sensing devices based on transducing the biochemical events to electrical signals. In this type of sensor, an electrode is a key component that is employed as a solid support for immobilization of biomolecules and electron movement. Thanks to numerous nanomaterials that possess the large surface area, synergic effects are enabled by improving loading capacity and the mass transport of reactants for achieving high performance in terms of analytical sensitivity. Main body: We categorized the current electrochemical biosensors into two groups, carbon-based (carbon nanotubes and graphene) and non-carbon-based nanomaterials (metallic and silica nanoparticles, nanowire, and indium tin oxide, organic materials). The carbon allotropes can be employed as an electrode and supporting scaffolds due to their large active surface area as well as an effective electron transfer rate. We also discussed the non-carbon nanomaterials that are used as alternative supporting components of the electrode for improving the electrochemical properties of biosensors. Conclusion: Although several functional nanomaterials have provided the innovative solid substrate for high performances, developing on-site version of biosensor that meets enough sensitivity along with high reproducibility still remains a challenge. In particular, the matrix interference from real samples which seriously affects the biomolecular interaction still remains the most critical issues that need to be solved for practical aspect in the electrochemical biosensor. Recently, various electrochemistry-driven biosensing methods have been introduced for simple and miniaturized analytical devices for on-site analysis. This trend can be applied to replace the commercial lab instruments manufactured by the renowned in vitro diagnosis

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“…Moreover, bio-inspired sensors involving the design of bio-mimic-recognized components, such as molecularly imprinted polymers, are also used for this purpose [121]. An interesting example is an electrochemical aptasensor for the determination of TNT involving the use of AgNPs and thiol-functionalized graphene quantum dots nanocomposite onto GCE and rutin as redox probe [122]. The same group prepared other biosensing surfaces for this nitroaromatic explosive [123].…”

Section: Electrochemical Biosensors For Chemical and Biological Weaponsmentioning

confidence: 99%

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

et al. 2019

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This article critically discusses the latest advances in the use of voltammetric, amperometric, potentiometric, and impedimetric biosensors for forensic analysis. Highlighted examples that show the advantages of these tools to develop methods capable of detecting very small concentrations of analytes and provide selective determinations through analytical responses, without significant interferences from other components of the samples, are presented and discussed, thus stressing the great versatility and utility of electrochemical biosensors in this growing research field. To illustrate this, the determination of substances with forensic relevance by using electrochemical biosensors reported in the last five years (2015–2019) are reviewed. The different configurations of enzyme or affinity biosensors used to solve analytical problems related to forensic practice, with special attention to applications in complex samples, are considered. Main prospects, challenges to focus, such as the fabrication of devices for rapid analysis of target analytes directly on-site at the crime scene, or their widespread use and successful applications to complex samples of interest in forensic analysis, and future efforts, are also briefly discussed.

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Designing an ultra-sensitive aptasensor based on an AgNPs/thiol-GQD nanocomposite for TNT detection at femtomolar levels using the electrochemical oxidation of Rutin as a redox probe

Cited by 91 publications

References 43 publications

Carbon Dots and Graphene Quantum Dots in Electrochemical Biosensing

Carbon Dots and Graphene Quantum Dots in Electrochemical Biosensing

Electrochemical biosensors: perspective on functional nanomaterials for on-site analysis

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

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