Designing and Binding Mode Prediction of Juvenile Hormone Analogues as Potential Inhibitor for Galleria mellonella

Abstract

Virtual screening of chemical databases has become an integral part of ligand design. Docking is one of the most important methods in computer assisted screening. If a three dimensional structure of target receptor is available, along with information regarding nature of the ligand-binding site, ligand-binding mode; the interactions between the ligand and receptor can be studied extensively, in order to design and develop target specific new compounds in a short time period. Juvenile Hormone Analogues, sesqui-terpenoid series of compound act as an insect growth regulator, and presently in use as a potential environment friendly pesticide. Juvenile hormone is the molting hormone responsible for each molt, and involved in a wide range of physiological processes in both developing and mature insect. Designing of various juvenile hormone analogues are new and emerging area to counter the insect problem.In this paper, we report protein-ligand interactions using a standard protocol of docking. We perform screening of synthesized (A-B) and proposed (C-D) series of Juvenile Hormone Analogues with hemolymph binding proteins of Galleria mellonella. Further binding energy profile of all the series have been compared with the phenoxy derivatives of juvenile hormone mimics, as well as natural JH III, in order to design targeted JHAs with improved biological activities. Our proposed series of juvenile hormone analogues exhibit better energy profile over in use phenoxy derivatives.

Influence of Some Honey Bee Products and Plant Oils on the Greater Wax Moth, Galleria mellonella L. (Lepidoptera: Pyralidae)

“…The warm temperature promotes the rapid development of this month, so it is found in temperate, tropical and sub-tropical beekeeping areas (Chandel et al, 2003;Mohamed et al, 2014). Adults do not feed because they have atrophy in the mouth, but the damage happened during the larval stage due to the voracious feeding of the larvae which leads to the destruction of the honeycomb (Awasthi and Sharma, 2013;Ellis et al, 2013;Kwadha et al, 2017). Larvae cause great damage to beeswax combs that the bees have left unattended; resulting heavy economic losses for beekeepers (Van Engelsdorp et al, Mahmoud M.A.…”

Toxicity and Bio-Efficacy of Indole-3-Acetic Acid, A Plant Growth Regulator, Against the Greater Wax Moth, Galleria mellonella Linnaeus (Lepidoptera: Pyralidae)

“…Although the adults of G. mellonella do not feed, because they have atrophied or ill-developed mouth parts, the voracious feeding nature of its larvae leads to the destruction of the honeycomb, and subsequent to the death of weak colonies (Ellis et al, 2013;Elbehery et al, 2016). Furthermore, it can destroy wax combs either inside or outside the hives (Awasthi and Sharma, 2013;Kwadha et al, 2017). Besides damaging wax combs and destroying frames and wooden parts in the hive, adults and larvae of G. mellonella can transfer pathogens of serious bee diseases, e.g.…”

Toxicity and Deleterious Impacts of the Deathstalker Scorpion, Leiurus quinquestriatus, Venom on Development of the Greater Wax Moth, Galleria mellonella (Lepidoptera: Pyralidae)

“…Its presumed native range includes Europe and adjacent Eurasia, and was introduced into other continents, including North America and Australia (Savela, 2009). Although the adults do not feed, because they have atrophied mouth parts, the voracious nature of larval feeding and tunneling lead to the destruction of the honeycomb, and subsequent to the death of weak colonies (Awasthi and Sharma, 2013;Kwadha et al, 2017), especially in temperate, tropical and subtropical beekeeping regions, since the warm temperature enhances a rapid development of this moth (Chandel et al, 2003;Ellis et al, 2013;Mohamed et al, 2014).…”