Designing artificial anterior cruciate ligaments based on novel fibrous structures

Cruz, Juliana; Rana, Sohel; Fangueiro, Raúl; Guedes, Rui Miranda

doi:10.1007/s12221-014-0181-4

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…Some increase in stent's length can also be noticed. Although, stent diameter could not recover completely back to the original values, the diameter recovery was more than 80% (Table 2), which is comparable with the value obtained with previously reported polypropylene stents [7]. …”

Section: Diameter Recovery and Extension In Lengthsupporting

confidence: 89%

“…Possibility of producing bioabsorbable braided stents has been explored using PLLA fibres [7] and the produced stents showed similar radial pressure stiffness to metallic stents and maintained, at least, half of their radial pressure stiffness for more than 22 weeks. These initial research studies on braided stents investigated separately the influence of some of the design parameters on selected properties of stents such as radial compression.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Moreover, braiding technique is a simple and versatile process, providing the structures high compliance level, torsional stability and wear resistance [4]. Braided structures have been well studied for application in medical implantable devices like sutures, artificial ligaments, etc [7,8]. A few studies have demonstrated the possibility of using braided structures for producing self-expanding stents.…”

Section: Introductionmentioning

confidence: 99%

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Influence of design parameters on the mechanical behavior and porosity of braided fibrous stents

et al. 2015

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Section: Diameter Recovery and Extension In Lengthsupporting

confidence: 89%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of design parameters on the mechanical behavior and porosity of braided fibrous stents

et al. 2015

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“…These features, and the even distribution of the load, impart crack resistance to the braided structure. Owing to the effectiveness and versatility of the processes, laying/braiding is still generally used to manufacture artificial tendons and ligaments. , To build a hierarchical assembly of hydrogel strands, Alg/PAM DN hydrogel ropes were prepared by laying (two strands) and braiding (three and four strands) Alg/PAM hydrogel strands, and subsequently, the RsEC process was applied (Figure a). As shown, highly stretched and coiled complex structures can be manufactured using braiding and the RsEC process, resulting in a hierarchical, complex structure of anisotropic hydrogels, which are analogues of collagen fibers comprising assembled collagen fibrils.…”

Section: Results and Discussionmentioning

confidence: 99%

Anisotropic Hydrogels with a Multiscale Hierarchical Structure Exhibiting High Strength and Toughness for Mimicking Tendons

Park

Kim

2021

ACS Appl. Mater. Interfaces

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Owing to their anisotropic and hierarchical structure, tendons exhibit an outstanding mechanical performance despite the low polymer concentration and softness of the constituent materials. Here, we propose a tendon-mimicking, strong, and tough hydrogel with a multiscale hierarchical and anisotropic structure. An isotropic, precursor double-network hydrogel is transformed into an anisotropic hydrogel by stretching, solvent exchange, and subsequent fixation via ionic crosslinking. Solvent exchange induces densification of the stretched polymer network, enhancement of linear alignment of polymer chains, and microphase separation, leading to anisotropic toughening of the hydrogel. The resulting anisotropic hydrogels show high strength and toughness, which vary over a wide range (1.2−3.3 MPa of strength and 4.9−8.8 MJ/m 3 of toughness, respectively), controlled by the degree of pre-stretching. Furthermore, a hierarchical architecture is constructed by braiding the anisotropic hydrogel strands into a rope, resulting in an improved mechanical performance (4.7 MPa of strength in a four-strand hydrogel rope) compared to separated unbraided strands of a hydrogel (2.3 MPa of strength). The higher hierarchical hydrogel cable, prepared by braiding four hydrogel ropes, can withstand a heavy load even up to 13 kg. These results represent that a hierarchical assembly of anisotropic hydrogels exhibits high mechanical performance and a hierarchically anisotropic structure, which are reminiscent of tendons.

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“…Stress-strain curves were plotted for each tested sample. The J-shape characteristic of gelatin-based electrospun scaffolds ( Huang et al, 2004 ) and biological soft tissue ( Cruz et al, 2014 ), was found in each gelatin-based electrospun scaffolds manufactured. This J-shape is typically shown to have a toe-region where the fibers start to straighten in the direction of the applied load and recover their structure once load has been removed, a linear region where the Young’s modulus was calculated for each sample, and the yield region.…”

Section: Resultsmentioning

confidence: 99%

Can we achieve biomimetic electrospun scaffolds with gelatin alone?

Roldán

Reeves

Cooper

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Gelatin is a natural polymer commonly used in biomedical applications in combination with other materials due to its high biocompatibility, biodegradability, and similarity to collagen, principal protein of the extracellular matrix (ECM). The aim of this study was to evaluate the suitability of gelatin as the sole material to manufacture tissue engineering scaffolds by electrospinning.Methods: Gelatin was electrospun in nine different concentrations onto a rotating collector and the resulting scaffold’s mechanical properties, morphology and topography were assessed using mechanical testing, scanning electron microscopy and white light interferometry, respectively. After characterizing the scaffolds, the effects of the concentration of the solvents and crosslinking agent were statistically evaluated with multivariate analysis of variance and linear regressions.Results: Fiber diameter and inter-fiber separation increased significantly when the concentration of the solvents, acetic acid (HAc) and dimethyl sulfoxide (DMSO), increased. The roughness of the scaffolds decreased as the concentration of dimethyl sulfoxide increased. The mechanical properties were significantly affected by the DMSO concentration. Immersed crosslinked scaffolds did not degrade until day 28. The manufactured gelatin-based electrospun scaffolds presented comparable mechanical properties to many human tissues such as trabecular bone, gingiva, nasal periosteum, oesophagus and liver tissue.Discussion: This study revealed for the first time that biomimetic electrospun scaffolds with gelatin alone can be produced for a significant number of human tissues by appropriately setting up the levels of factors and their interactions. These findings also extend statistical relationships to a form that would be an excellent starting point for future research that could optimize factors and interactions using both traditional statistics and machine learning techniques to further develop specific human tissue.

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Designing artificial anterior cruciate ligaments based on novel fibrous structures

Cited by 6 publications

References 16 publications

Influence of design parameters on the mechanical behavior and porosity of braided fibrous stents

Influence of design parameters on the mechanical behavior and porosity of braided fibrous stents

Anisotropic Hydrogels with a Multiscale Hierarchical Structure Exhibiting High Strength and Toughness for Mimicking Tendons

Can we achieve biomimetic electrospun scaffolds with gelatin alone?

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