Designing biomimetic scaffolds for skin tissue engineering

Abstract

There is a general increase in the number of patients with non-healing skin wounds, imposing a huge social and economic burden on patients and healthcare systems. Severe skin injury is...

Chiral nanomaterials in tissue engineering

“…These reviews explore novel designs of biomaterials and scaffolds aimed at generating biomimetic or hierarchical tissues. 165,166 Additionally, refined delivery strategies for drugs and bioactive molecules, 167 including extracellular vesicles, 168–170 have been discussed. Mechanistic insights into cell–material interactions, such as the influence of substrate stiffness and topography, 6,171 have been summarized, as well as the current understanding of biological responses to foreign materials.…”

Combining Step‐Growth and Chain‐Growth Polymerizations in One Pot: Light‐Induced Fabrication of Conductive Nanoporous PEDOT‐PCL Scaffold

“…[11] These distinctive features have positioned PEDOTs as an attractive candidate for the fabrication of biodegradable and electroconductive polymers, particularly in the field of tissue engineering (TE) scaffolds. [12][13][14][15][16][17] In general, TE scaffolds are designed to be nanoporous, electroconductive, and biodegradable structures that can provide temporary support for tissue. [18][19][20][21] However, a critical challenge lies in the fact that PEDOTs, along with many other CPs, exhibit low or non-biodegradability, brittleness, and insolubility.…”

Encapsulation of Sericin-Decorated Efficient Agents in Silk Hydrogels for Wound Dressings

“…8,9 Cellulose, chitosan, hyaluronic acid, collagen, silk fibroin (SF), alginate, gelatin, and many other natural polymers have been studied to fabricate hydrogel dressings through solvent casting, physical/chemical crosslinking, 3D printing, and self-assembly. 1,10 In order to enhance the efficiency of skin regeneration, researchers have developed advanced multieffect wound dressings that incorporate bioactive agents, such as drugs, stem cells, growth factors, antimicrobial agents, and antioxidants, into natural polymer-based hydrogels. 11,12 Specifically, to impart antibacterial properties to the hydrogels, various antibacterial drugs like antibiotics and steroids are commonly encapsulated.…”

“…Skin serves as a protective barrier against external stimuli, such as pathogens, chemicals, and heat. Skin injuries occur commonly around the world due to various reasons, for example, trauma and surgery may cause physical skin injuries, while chemicals and heat may cause skin burns. , When the skin is injured, it becomes susceptible to bacterial invasion and delayed or inappropriate treatments can impede the healing process, trigger immune responses, and lead to systemic issues and physical impairments. Therefore, proper wound management is crucial to protect the injured skin from secondary damage and bacterial infections.…”

“…Currently, wound dressing is the most commonly applied approach to treat skin injuries. , An ideal wound dressing should possess several advantages, including mechanical strength, antibacterial activity, anti-inflammatory activity, biocompatibility, biodegradability, and cost-effectiveness. − Various types of materials have been developed as wound dressings, including foams, films, nanofibers, sponges, hydrogels, and functional gauze. Among these options, natural polymer-based hydrogels have garnered increasing attention due to their excellent biocompatibility, ease of removal, and ability to maintain a physiologically moist microenvironment at the wound site. , Cellulose, chitosan, hyaluronic acid, collagen, silk fibroin (SF), alginate, gelatin, and many other natural polymers have been studied to fabricate hydrogel dressings through solvent casting, physical/chemical cross-linking, 3D printing, and self-assembly. , …”