Designing dendrimers for ocular drug delivery

Spataro, Grégory; Malecaze, F; Turrin, Cédric‐Olivier; Soler, V.; Duhayon, Carine; Elena, Pierre-Paul; Majoral, Jean‐Pierre; Caminade, Anne‐Marie

doi:10.1016/j.ejmech.2009.10.017

Cited by 150 publications

(87 citation statements)

References 57 publications

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“…36,37 Como os principais determinantes das propriedades dos dendrímeros, temos a sua geração (relacionada com o peso molecular) e o grupo terminal que afetarão parâmetros como solubilidade, eficácia, bioadesão e farmacocinética. [38][39][40][41][42] A literatura de dendrímeros para a terapia gené-tica ocular ainda é relativamente recente, contando com um número limitado de trabalhos. Dessa maneira, ainda é cedo para predizer o futuro desses sistemas, mesmo já existindo reagentes de transfecção comerciais baseados em dendrímeros (SuperFect ® , Qiagen ® ).…”

Section: Vetores Não Virais Com Base Nanotecnológica Para a Via Ocularunclassified

Biomateriais para formulações de base nanotecnológica visando terapia gênica ocular

et al. 2016

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Section: Vetores Não Virais Com Base Nanotecnológica Para a Via Ocularunclassified

Biomateriais para formulações de base nanotecnológica visando terapia gênica ocular

et al. 2016

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“…Due to the very low solubility of the second generation, the quantity of carteolol instilled is low, but the quantity of carteolol that penetrates inside the eyes is larger than expected, when compared with carteolol alone (2.5 times larger). These pharmacodynamic observations highlight the biocompatibility and the potential usefulness of the phosphorhydrazone dendrimers for drug delivery (Spataro et al, 2010).…”

Section: Phosphorhydrazone Dendrimers En-ded By Carboxylate Groupsmentioning

confidence: 99%

Biological properties of water-soluble phosphorhydrazone dendrimers

Caminade

Turrin

Majoral

2013

Braz. J. Pharm. Sci.

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1984-8250Dendrimers are hyperbranched and perfectly defined macromolecules, constituted of branches emanating from a central core in an iterative fashion. Phosphorhydrazone dendrimers constitute a special family of dendrimers, possessing one phosphorus atom at each branching point. The internal structure of these dendrimers is hydrophobic, but hydrophilic terminal groups can induce the solubility of the whole structure in water. Indeed, the properties of these compounds are mainly driven by the type of terminal groups their bear; this is especially true for the biological properties. For instance, positively charged terminal groups are efficient for transfection experiments, as drug carriers, as anti-prion agents, and as inhibitor of the aggregation of Alzheimer's peptides, whereas negatively charged dendrimers have anti-HIV properties and can influence the human immune system, leading to anti-inflammatory properties usable against rheumatoid arthritis. This review will give the most representative examples of the biological properties of water-soluble phosphorhydrazone dendrimers, organized depending on the type of terminal groups they bear

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“…The reaction with carteolol, an anti-hypertensive drug for the treatment of glaucoma, led to a dendritic salt, which was solubilized in water and dropped in the eyes of rabbits. No irritation was observed, and the quantity of carteolol measured in the aqueous humor was increased compared to neat carteolol, presumably thanks to an increased time of residence of carteolol in the eye when interacting with the dendrimer [26]. A last example concerns an ammonium group used as core of phosphorus dendrimers having carboxylic acids as terminal functions.…”

Section: Functional Cores Of Dendrimers (Type A)mentioning

confidence: 99%

Bifunctional Phosphorus Dendrimers and Their Properties

Caminade

Majoral

2016

Molecules

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Dendrimers are hyperbranched and monodisperse macromolecules, generally considered as a special class of polymers, but synthesized step-by-step. Most dendrimers have a uniform structure, with a single type of terminal function. However, it is often desirable to have at least two different functional groups. This review will discuss the case of bifunctional phosphorus-containing dendrimers, and the consequences for their properties. Besides the terminal functions, dendritic structures may have also a function at the core, or linked off-center to the core, or at the core of dendrons (dendritic wedges). Association of two dendrons having different terminal functions leads to Janus dendrimers (two faces). The internal structure can also possess functional groups on one layer, or linked to one layer, or on several layers. Finally, there are several ways to have two types of terminal functions, besides the case of Janus dendrimers: either each terminal function bears two functions sequentially, or two different functions are linked to each terminal branching point. Examples of each type of structure will be given in this review, as well as practical uses of such sophisticated structures in the fields of fluorescence, catalysis, nanomaterials and biology.

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Designing dendrimers for ocular drug delivery

Cited by 150 publications

References 57 publications

Biomateriais para formulações de base nanotecnológica visando terapia gênica ocular

Biomateriais para formulações de base nanotecnológica visando terapia gênica ocular

Biological properties of water-soluble phosphorhydrazone dendrimers

Bifunctional Phosphorus Dendrimers and Their Properties

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