A truly effective program of handling medical practice disputes continues to elude the traditional justice system, despite numerous attempts at using mediation and other forms of alternative dispute resolution (ADR). A comprehensive review of the legal, social, and psychological aspects of medical practice disputes, as well as the history of malpractice mediation, reveals many of the reasons for this failure. Mediation is highly appropriate for these cases, but a different approach, grounded in conflict resolution theory, would be much more effective.