Designing Kappa-carrageenan/guar gum/polyvinyl alcohol-based pH-responsive silane-crosslinked hydrogels for controlled release of cephradine

Farooq, Amna; Farooq, Ameeq; Jabeen, Sobia; Islam, Atif; Gull, Nafisa; Khan, Rafi Ullah; Haq, H.M. Shifa ul; Mehmood, Azra; Hussain, N.; Bilal, Muhammad

doi:10.1016/j.jddst.2021.102969

Cited by 15 publications

(3 citation statements)

References 37 publications

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“…Furthermore, hydrogels may form a conformable interface with biological surfaces by fine-tuning their rheological properties (i.e., viscosity) to adjust the retention time. To elaborate, utilizing the anionic or cationic functional groups within the polymer components, researchers have developed pH-sensitive hydrogels for controlling drugs under different circumstances. − Table summarizes the synthetic and natural hydrogels for obesity treatments.…”

Section: Pharmaceuticals and Polymeric Biomaterials Carriersmentioning

confidence: 99%

Current Role and Potential of Polymeric Biomaterials in Clinical Obesity Treatment

2023

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The rise of obesity and associated fatal diseases has taken a massive toll worldwide. Despite the existing pharmaceuticals and bariatric surgeries, these approaches manifest limited efficacy or accompany various side effects. Therefore, researchers seek to facilitate the prolonged and specific delivery of therapeutics. Or else, to mimic the essential part of "gastric bypass" by physically blocking excessive absorption via less invasive methods. To achieve these goals, polymeric biomaterials have gained tremendous interest recently. They are known for synthesizing hydrogels, microneedle patches, mucoadhesive coatings, polymer conjugates, and so forth. In this Review, we provide insights into the current studies of polymeric biomaterials in the prevention and treatment of obesity, inspiring future improvements in this regime of study.

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Section: Pharmaceuticals and Polymeric Biomaterials Carriersmentioning

confidence: 99%

Current Role and Potential of Polymeric Biomaterials in Clinical Obesity Treatment

2023

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“…However, as a drug delivery carrier, the usage of guar gum is limited because of its high swelling characteristics in aqueous media. A representative study by Amna Farooq et al in 2022 used silane as a crosslinker to prepare pH-sensitive hydrogels [115]. They used vinyltriethoxy silane (VTEOS) to optimize Kappa-carrageenan (KC)/guar gum (GG)/poly(vinyl alcohol) (PVA)'s high swelling characteristics.…”

Section: Guar Gummentioning

confidence: 99%

Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications

Liang

Shen

et al. 2022

Pharmaceutics

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Carbohydrates, one of the most important compounds in living organisms, perform numerous roles, including those associated with the extracellular matrix, energy-related compounds, and information. Of these, polymeric carbohydrates are a class of substance with a long history in drug delivery that have attracted more attention in recent years. Because polymeric carbohydrates have the advantages of nontoxicity, biocompatibility, and biodegradability, they can be used in drug targeting, sustained drug release, immune antigens and adjuvants. In this review, various carbohydrate-based or carbohydrate-modified drug delivery systems and their applications in disease therapy have been surveyed. Specifically, this review focuses on the fundamental understanding of carbohydrate-based drug delivery systems, strategies for application, and the evaluation of biological activity. Future perspectives, including opportunities and challenges in this field, are also discussed.

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“…There are many studies in the literature in which carrageenan-based hydrogel formulations with controlled release of drugs are prepared. [15,17,18].…”

Section: Introductionmentioning

confidence: 99%

A new approach to oral dosage forms: carrageenan-based vegan gummies

Ezgi GÜLTEKİN,

İLHAN,

NALBANTOĞLU

2024

jrp

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Designing Kappa-carrageenan/guar gum/polyvinyl alcohol-based pH-responsive silane-crosslinked hydrogels for controlled release of cephradine

Cited by 15 publications

References 37 publications

Current Role and Potential of Polymeric Biomaterials in Clinical Obesity Treatment

Current Role and Potential of Polymeric Biomaterials in Clinical Obesity Treatment

Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications

A new approach to oral dosage forms: carrageenan-based vegan gummies

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