Designing M13 Bacteriophage and Fe-Nanonest Self-Assembly System for Universal and Facile Preparation of Metal Single Atoms as Stable Mimicking Enzymes

Qi, Wenjing; Song, Mingye; Wang, Miaomiao; Yu, Huimin

doi:10.1021/acsnano.3c09224

ACS Nano

2023

DOI: 10.1021/acsnano.3c09224

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Designing M13 Bacteriophage and Fe-Nanonest Self-Assembly System for Universal and Facile Preparation of Metal Single Atoms as Stable Mimicking Enzymes

Wenjing Qi,

Mingye Song,

Miaomiao Wang

et al.

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2024

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Cited by 7 publications

References 67 publications

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Exploring Nanozymes for Organic Substrates: Building Nano‐organelles

Liu,

Gao,

Qin

et al. 2024

Angewandte Chemie

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Since the discovery of the first peroxidase nanozyme (Fe3O4), numerous nanomaterials have been reported to exhibit intrinsic enzyme‐like activity toward inorganic oxygen species, such as H2O2, oxygen, and O2•‐. However, the exploration of nanozymes targeting organic compounds holds transformative potential in the realm of industrial synthesis. This review provides a comprehensive overview of the diverse types of nanozymes that catalyze reactions involving organic substrates and discusses their catalytic mechanisms, structure‐activity relationships, and methodological paradigms for discovering new nanozymes. Additionally, we propose a forward‐looking perspective on designing nanozyme formulations to mimic subcellular organelles, such as chloroplasts, termed “nano‐organelles”. Finally, we analyze the challenges encountered in nanozyme synthesis, characterization, nano‐organelle construction and applications while suggesting directions to overcome these obstacles and enhance nanozyme research in the future. Through this review, our goal is to inspire further research efforts and catalyze advancements in the field of nanozymes, fostering new insights and opportunities in chemical synthesis.

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Exploring Nanozymes for Organic Substrates: Building Nano‐organelles

Liu,

Gao,

Qin

et al. 2024

Angewandte Chemie

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Exploring Nanozymes for Organic Substrates: Building Nano‐organelles

Liu,

Gao,

Qin

et al. 2024

Angew Chem Int Ed

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Phage‐Templated Synthesis of Targeted Photoactive 1D‐Thiophene Nanoparticles

Costantini,

Saporetti,

Iencharelli

et al. 2024

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Thiophene‐based nanoparticles (TNPs) are promising therapeutic and imaging agents. Here, using an innovative phage‐templated synthesis, a strategy able to bypass the current limitations of TNPs in nanomedicine applications is proposed. The phage capsid is decorated with oligothiophene derivatives, transforming the virus in a 1D‐thiophene nanoparticle (1D‐TNP). A precise control of the shape/size of the nanoparticles is obtained exploiting the well‐defined morphology of a refactored filamentous M13 phage, engineered by phage display to selectively recognize the Epidermal Growth Factor Receptor (EGFR). The tropism of the phage is maintained also after the bioconjugation of the thiophene molecules on its capsid. Moreover, the 1D‐TNP proved highly fluorescent and photoactive, generating reactive oxygen species through both type I and type II mechanisms. The phototheranostic properties of this platform are investigated on biosystems presenting increasing complexity levels, from in vitro cancer cells in 2D and 3D architectures, to the in vivo tissue‐like model organism Hydra vulgaris. The phage‐templated 1D‐TNP showed photocytotoxicity at picomolar concentrations, and the ability to deeply penetrate 3D spheroids and Hydra tissues. Collectively the results indicate that phage‐templated synthesis of organic nanoparticles represents a general strategy, exploitable in many diagnostic and therapeutic fields based on targeted imaging and light mediated cell ablation.

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Designing M13 Bacteriophage and Fe-Nanonest Self-Assembly System for Universal and Facile Preparation of Metal Single Atoms as Stable Mimicking Enzymes

Cited by 7 publications

References 67 publications

Exploring Nanozymes for Organic Substrates: Building Nano‐organelles

Exploring Nanozymes for Organic Substrates: Building Nano‐organelles

Exploring Nanozymes for Organic Substrates: Building Nano‐organelles

Phage‐Templated Synthesis of Targeted Photoactive 1D‐Thiophene Nanoparticles

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