Based on the backlight module (BLM) with an integrated micro-optical light guide plate (MOLGP) that we proposed [Opt. Express21, 20159 (2013)], an optical model that maps the relationship between the distribution of microprisms on the bottom surface of the integrated MOLGP and the luminance of the output light is established by a backpropagation neural network in this paper. Then the optimized distribution of the microprisms for high luminance uniformity of the output light is obtained by a genetic algorithm. Finally, the integrated BLM with the optimized distribution of microprisms on the bottom surface of the integrated MOLGP is set up in optical software, and the simulation results show that the luminance uniformity of the output light in this BLM reaches 93%.