Designing of dynamic polyethyleneimine (PEI) brushes on polyurethane (PU) ureteral stents to prevent infections

Gultekinoglu, Merve; Sarisozen, Yeliz Tunc; Erdoğdu, Ceren; Sağıroğlu, Meral; Aksoy, Eda Ayşe; Oh, Yoo Jin; Hinterdorfer, Peter; Ulubayram, Kezban

doi:10.1016/j.actbio.2015.03.037

Cited by 57 publications

(48 citation statements)

References 46 publications

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“…25,35,[44][45][46][47][68][69][70][71][72][76][77][78][79][80]84,85,[95][96][97][98][99][100][101] These coatings primarily function through either a disruption of the bacterial membrane using cationic charges or hydrophobic interactions repelling the adherence of bacteria. The benefit of these coatings is that they are primarily non-leaching coatings and therefore demonstrate long-term intrinsic antibacterial activity, are biocompatible, and do not cause any significant cytotoxicity.…”

Section: Polymer-based Coatingsmentioning

confidence: 99%

“…Beyond QASs, different cationic polymer brushes such as polyethyleneimine (PEI) have been grafted onto polyurethane catheters to prevent bacterial adhesion and biofilm formation. 45 The rationale behind using cationic polymers is that they are capable of penetrating the negatively charged membranes of bacterial cells ultimately causing necrosis. 76 Specifically, Gultekinoglu et al 45 modified the PEI brushes with bromohexane to improve their ability to disrupt bacterial membranes.…”

Section: Polymer-based Coatingsmentioning

confidence: 99%

“…45 The rationale behind using cationic polymers is that they are capable of penetrating the negatively charged membranes of bacterial cells ultimately causing necrosis. 76 Specifically, Gultekinoglu et al 45 modified the PEI brushes with bromohexane to improve their ability to disrupt bacterial membranes. The grafted materials were capable of inhibiting the growth of Klebsiella pneumonia, E. coli, and Proteus mirabilis and demonstrated no cytotoxicity.…”

Section: Polymer-based Coatingsmentioning

confidence: 99%

“…The advantage of these coatings is that they intrinsically possess antibacterial and antifungal properties without the use of drugs and have the potential for much longer lasting applications than drug-eluting coatings. 45 In this paper, an overview of affinity-based device coatings will be presented along with a review of non-drug approaches for antibacterial coatings.…”

Section: Introductionmentioning

confidence: 99%

“…11,38 Alternatively, other groups have taken another approach altogether to reduce these detrimental effects yet still obtain antibacterial device coatings. Specifically, many groups have worked on developing metallic-based [39][40][41][42][43] and polymer-based 35,[44][45][46][47] non-drug-eluting coatings. The advantage of these coatings is that they intrinsically possess antibacterial and antifungal properties without the use of drugs and have the potential for much longer lasting applications than drug-eluting coatings.…”

Section: Introductionmentioning

confidence: 99%

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Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Cyphert

Recum

2017

Exp Biol Med (Maywood)

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This work provides an overview, with advantages and limitations of the most recently developed antibacterial coating technologies, enabling other researchers in the field to more easily determine which technology is most advantageous for them to further develop and pursue. AbstractOver the past 20 years, the field of antimicrobial medical device coatings has expanded nearly 30-fold with technologies shifting their focus from diffusion-only based (short-term antimicrobial eluting) coatings to long-term antimicrobial eluting and intrinsically antimicrobial functioning materials. A variety of emergent coatings have been developed with the goal of achieving long-term antimicrobial activity in order to mitigate the risk of implanted device failure. Specifically, the coatings can be grouped into two categories: those that use antibiotics in conjunction with a polymer coating and those that rely on the intrinsic properties of the material to kill or repel bacteria that come into contact with the surface. This review covers both long-term drug-eluting and non-eluting coatings and evaluates the inherent advantages and disadvantages of each type while providing an overview of variety applications that the coatings have been utilized in.

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Section: Polymer-based Coatingsmentioning

confidence: 99%

Section: Polymer-based Coatingsmentioning

confidence: 99%

Section: Polymer-based Coatingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Cyphert

Recum

2017

Exp Biol Med (Maywood)

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Synthesis of biodegradable polyurethanes chain‐extended with (2S)‐bis(2‐hydroxypropyl) 2‐aminopentane dioate

Aksoy

Taşkor

Gultekinoglu

et al. 2017

J of Applied Polymer Sci

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Polyurethanes (PUs) are the most widely used polymers because of their biocompatibility, tunable mechanical properties, and chemical versatility. In this study, a two-step condensation polymerization of polycaprolactone diol and hexamethylene diisocyanate was carried out, and a glutamic acid ester derivative, (2S)-bis(2-hydroxypropyl) 2-aminopentane dioate (HPAP), was used as a new chain extender to accelerate the biodegradation properties of PU. HPAP was synthesized by the Fischer esterification of L-glutamic acid. The chemical structure of HPAP was confirmed by high-resolution mass spectroscopy and m/z (EI) was found to be 264.1447 [calculated value 5 264.1443 for C 11 H 21 NO 6 (M 1 )]. The Berry plot of static light-scattering measurements showed that PU-HPAP had a weight-average molecular weight and radius of gyration of 33,100 g/mol and 1420 nm, respectively. The presence of HPAP in the PU structure facilitated hydrogen bonding between the polymer chains and increased the glass-transition temperature from 256 8C (PU) to 250 8C (PU-HPAP). PU-HPAP showed the highest hydrophilicity and surface free energy among all of samples, and this accelerated the in vitro biodegradation period via surface erosion. In addition, PU-HPAP did not show any cytotoxic effects on the L929 cells. A new biodegradable and biocompatible PU-HPAP was obtained as candidate for tissue engineering applications.

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Polyurethane‐basedcomposites with promising antibacterial properties

Kasi

Sathishkumar

Zhang

et al. 2022

J of Applied Polymer Sci

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Polyurethane (PU) is a well-known synthetic polymer consisting of isocyanates, polyols, and chain extenders. The incorporation of fillers into the PU polymeric matrix, including inorganic nanomaterials, synthetic polymers, natural components, quaternary ammonium salts, and commercial drugs, bestows the endproducts with unique and improved physicochemical properties. Fillers can be used to tailor the molecular orientation, crystallinity, cross-linking, and functional chemical groups of PU-based composites. The bactericidal ability of PU composites highly depends on their surface composition, morphology, charge, and stability. Recent advancements highlight the potential of PU composites in combating bacterial infections. In this review, the cutting-edge of inorganic and organicbased PU composites for antibacterial applications is addressed. Notably, selective examples of scientific reports' key findings and their crucial information on PU composites are discussed. Furthermore, the positive impact of PU composites on the future prospects of this field is explored. This review comprehensively deliberates the values of PU composites towards practical applications in the biomedical field of antibacterial activity. This review can help researchers to gain widespread knowledge and a better understanding of PU composites for antibacterial applications.

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Designing of dynamic polyethyleneimine (PEI) brushes on polyurethane (PU) ureteral stents to prevent infections

Cited by 57 publications

References 46 publications

Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Synthesis of biodegradable polyurethanes chain‐extended with (2S)‐bis(2‐hydroxypropyl) 2‐aminopentane dioate

Polyurethane‐basedcomposites with promising antibacterial properties

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