Designing of new cationic surfactant based micellar systems as drug carriers: an investigation into the drug cell membrane interactions

Talat, Rabia; Fayyaz, Summaira; Ali, Saqib; Khalid, Nasir; Haider, Ali; Shah, Afzal; Ullah, Faizan

doi:10.1080/01932691.2018.1489279

Cited by 11 publications

(3 citation statements)

References 46 publications

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“…Pyridine-based cationic surfactant was synthesized ( Scheme S1 ) according to our reported method with slight modification [ 25 , 26 ]. Briefly, surfactant was synthesized by refluxing equimolar amounts of 3-methyl pyridine (0.20 g; 2.15 mmol) and tridecyl bromide (0.57 g; 2.15 mmol) in 25 mL dried toluene as a solvent for 10 h. After cooling to room temperature, the reaction mixture was filtered off and the brownish viscous compound was obtained by rotary evaporation.…”

Section: Methodsmentioning

confidence: 99%

Binder-Free Fabrication of Prussian Blue Analogues Based Electrocatalyst for Enhanced Electrocatalytic Water Oxidation

et al. 2022

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Developing a cost-effective, efficient, and stable oxygen evolution reaction (OER) catalyst is of great importance for sustainable energy conversion and storage. In this study, we report a facile one-step fabrication of cationic surfactant-assisted Prussian blue analogues (PBAs) Mx[Fe(CN)5CH3C6H4NH2]∙yC19H34NBr abbreviated as SF[Fe-Tol-M] (where SF = N-tridecyl-3-methylpyridinium bromide and M = Mn, Co and Ni) as efficient heterogeneous OER electrocatalysts. The electrocatalysts have been characterized by Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) coupled with energy dispersive X-ray (EDX) analysis, and X-ray photoelectron spectroscopy (XPS). In the presence of cationic surfactant (SF), PBAs-based electrodes showed enhanced redox current, high surface area and robust stability compared to the recently reported PBAs. SF[Fe-Tol-Co] hybrid catalyst shows superior electrochemical OER activity with a much lower over-potential (610 mV) to attain the current density of 10 mA cm−2 with the Tafel slope value of 103 mV·dec−1 than that for SF[Fe-Tol-Ni] and SF[Fe-Tol-Mn]. Moreover, the electrochemical impedance spectroscopy (EIS) unveiled that SF[Fe-Tol-Co] exhibits smaller charge transfer resistance, which results in a faster kinetics towards OER. Furthermore, SF[Fe-Tol-Co] offered excellent stability for continues oxygen production over extended reaction time. This work provides a surface assisted facile electrode fabrication approach for developing binder-free OER electrocatalysts for efficient water oxidation.

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Section: Methodsmentioning

confidence: 99%

Binder-Free Fabrication of Prussian Blue Analogues Based Electrocatalyst for Enhanced Electrocatalytic Water Oxidation

et al. 2022

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“…The amphiphilic nature of the surfactants is suggested to allow better adsorption at the solid/liquid interface [29], thereby blocking the reactive sites prone to degradation. Furthermore, the substituted pyridinium-based compounds are generally less toxic than unsubstituted ones, and they have many biological applications [30][31][32]. Herein, we present a study of the eco-friendly 1-alkyl-3-methylpyridinium bromide surfactants [33,34] prepared by us, and evaluated for the corrosion protection of EN3B mild steel in strongly acidic chloride media (3.5% NaCl, pH 1.5) through the combination of conventional and state-ofthe-art technologies.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Corrosion Inhibition Efficiency of Pyridinium-Based Cationic Surfactants for EN3B Mild Steel in Acidic-Chloride Media

et al. 2022

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Two new effective corrosion inhibitors, namely N-(n-octyl)-3-methylpyridinium bromide (Py8) and N-(n-dodecyl)-3-methylpyridinium bromide (Py12), have been presented. The cationic pyridinium-based surfactants were analyzed for the corrosion protection of general purpose steel (EN3B) against a strong corrosive media (3.5% NaCl, pH 1.5). The results of the electrochemical measurements, i.e., Tafel polarization, linear polarization resistance (LPR) and electrochemical impedance spectroscopy (EIS) revealed a mixed-type behavior of both inhibitors, and the maximum inhibition efficiency (IE) achieved with Py8 and Py12 was 85% and 82%, respectively. The process of adsorption of synthesized inhibitors followed the Langmuir adsorption isotherm, and a higher value of Kads highlighted the existence of strong interaction between inhibitors and the EN3B mild steel surface. Furthermore, the values of ΔG°ads were calculated to be –32 kJ mol−1 for Py8 and –33 kJ mol−1 for Py12, indicating the coexistence of both physisorbed and chemisorbed molecules. The surface morphology of EN3B mild steel samples was observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM), where the reduced surface roughness in the presence of Py8 and Py12 in chloride media further supported the evidence of an efficient inhibition process. Density functional theory (DFT) calculations reveal excellent correlation with the experimental results, with Py8 showing superior corrosion inhibition potential, signifying that the alkyl chain length and intramolecular charge transfer are crucial factors in deciding the inhibition performance of the synthesized cationic surfactants. Furthermore, this study proposes the mechanism for the adsorption of the surfactant-based inhibitors over the EN3B mild steel surface, which leads to the formation of an effective and protective anticorrosive film.

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“…Surfactants have multitude of industrial applications and are used in cosmetics, corrosion inhibition, biocides, fabric softeners, emulsifier, detergents etc. Moreover they are effective bactericides and fungicides [6, 7, 8, 9, 10, 11, 12, 13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of cationic surfactants and their interactions with drug and metal complexes

Akhter

Ullah

Talat

et al. 2019

Heliyon

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Two new cationic surfactants, n-hexadecyl-3-methylpyridinium bromide and n-heptadecyl-3-methylpyridinium bromide have been synthesized and characterized in solid state by FT-IR, and in solution by 1 H- and 13 C-NMR spectroscopy. The values of critical micelle concentration (CMC) were determined by UV-visible spectroscopy and conductometry. Interaction of synthesized surfactants with two anionic drugs, i.e., diclofenac sodium {[2-(2, 6-Dichloroanilino) phenyl] acetic acid} and ketoprofen [(RS)-2-(3-benzoylphenyl) propionic acid] was studied by UV-visible spectroscopy. Binding constant (K), Gibb's free energy (ΔG) and number of drug molecules (n) per micelle were also calculated. These synthesized surfactants were proved to be efficient in increasing the solubility and bioavailability of drug molecules. In order to check the carrier efficiency of synthesized surfactants against bioactive coordinate, on complexes, interaction of recently reported bioactive zinc complexes was tested with synthesized cationic surfactants by conductometric measurements. Mole fractions (X cmc ) and Gibbs free energy (ΔG cmc ) values were also calculated. Both surfactants were further screened for anti-fungal and anti-bacterial activities.

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Designing of new cationic surfactant based micellar systems as drug carriers: an investigation into the drug cell membrane interactions

Cited by 11 publications

References 46 publications

Binder-Free Fabrication of Prussian Blue Analogues Based Electrocatalyst for Enhanced Electrocatalytic Water Oxidation

Binder-Free Fabrication of Prussian Blue Analogues Based Electrocatalyst for Enhanced Electrocatalytic Water Oxidation

Evaluating the Corrosion Inhibition Efficiency of Pyridinium-Based Cationic Surfactants for EN3B Mild Steel in Acidic-Chloride Media

Synthesis and characterization of cationic surfactants and their interactions with drug and metal complexes

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