Designing orodispersible films containing everolimus for enhanced compliance and bioavailability

Ma, Yang; Guan, Rou; Gao, Shuying; Wei, Song; Liu, Yubo; Yang, Yang; Liu, Hongzhuo

doi:10.1080/17425247.2020.1828342

Cited by 10 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Petri dish method was used to determine the disintegration time [21,22] of the LX-ODFs. Each petri dish was filled with10mL distilled water in which LX-ODFs of 4 cm 2 were placed.…”

Section: Disintegration Timementioning

confidence: 99%

Quality by Design Approach for Optimization and Development of Orodispersible Films of Lornoxicam Inclusion Complexes

Nerella

2022

HUJPHARM

View full text Add to dashboard Cite

Lornoxicam is a non-steroidal anti-inflammatory drug, indicated in the treatment of osteoarthritis and rheumatoid arthritis. Lornoxicam is a poor water-soluble drug and hence possesses dissolution limited bioavailability. The aim of the current research work was to develop and characterize orodispersible films of Lornoxicam to enhance its bioavailability by employing Quality-by-Design (QbD) approach. Solvent casting method was used to formulate the Lornoxicam mouth dissolving films. Three formulation factors viz. amount of polymer, amount of PEG 400 and type of polymer were varied at different levels. The responses selected were disintegration time and percent drug dissolved after 5mins. Under the response surface methodology, historical data design was employed to perform the statistical analysis using Design Expert software. The developed films were found to have good elasticity, folding endurance and favorable tensile strength. The disintegration time was found to be 9 to 17 seconds and drug dissolved after 5 minutes was 49 to 95%. The statistical analysis of the results by ANOVA elucidated that there was a significant effect of all the formulation factors on the selected responses (p

show abstract

“…Petri dish method was used to determine the disintegration time [21,22] of the LX-ODFs. Each petri dish was filled with10mL distilled water in which LX-ODFs of 4 cm 2 were placed.…”

Section: Disintegration Timementioning

confidence: 99%

Quality by Design Approach for Optimization and Development of Orodispersible Films of Lornoxicam Inclusion Complexes

Nerella

2022

HUJPHARM

View full text Add to dashboard Cite

show abstract

“…In vitro studies on drug release indicated that higher film thickness and polymer viscosity delayed the disintegration of the films and, consequently, the release of the drug [34]. HPMC E5 (6%, w/v) was chosen to prepare everolimus ODFs plasticized with propylene glycol, PEG400, or glycerol [35]. The formulations with propylene glycol were characterized by lower elongation at the break and a higher elastic modulus than those obtained from PEG 400, pointing to reduced elasticity and flexibility.…”

Section: Hydroxypropyl Cellulose (Hpc)mentioning

confidence: 99%

“…Those plasticized with PEG 400 were of better flexibility, with higher elongation and lower elastic modulus. Importantly, it was concluded that, when the concentration ratio of HPMC (E5) and PEG400 was 4:3, ODF exhibited the optimal mechanical features, acceptable thickness, disintegration time, and higher Young's modulus values, with lower percent elongation [35]. In another work, a full factorial experimental design was used to incorporate piroxicam into ODFs while studying the results of some formulation factors on the characteristics of the resulting films [36].…”

Section: Hydroxypropyl Cellulose (Hpc)mentioning

confidence: 99%

“Success Depends on Your Backbone”—About the Use of Polymers as Essential Materials Forming Orodispersible Films

2021

View full text Add to dashboard Cite

Polymers constitute a group of materials having a wide-ranging impact on modern pharmaceutical technology. Polymeric components provide the foundation for the advancement of novel drug delivery platforms, inter alia orodispersible films. Orodispersible films are thin, polymeric scraps intended to dissolve quickly when put on the tongue, allowing them to be easily swallowed without the necessity of drinking water, thus eliminating the risk of choking, which is of great importance in the case of pediatric and geriatric patients. Polymers are essential excipients in designing orodispersible films, as they constitute the backbone of these drug dosage form. The type of polymer is of significant importance in obtaining the formulation of the desired quality. The polymers employed to produce orodispersible films must meet particular requirements due to their oral administration and have to provide adequate surface texture, film thickness, mechanical attributes, tensile and folding strength as well as relevant disintegration time and drug release to obtain the final product characterized by optimal pharmaceutical features. A variety of natural and synthetic polymers currently utilized in manufacturing of orodispersible films might be used alone or in a blend. The goal of the present manuscript was to present a review about polymers utilized in designing oral-dissolving films.

show abstract

“…Moreover, the addition of flavor enhancers or the use of API flavor-masking technologies can greatly increase the preference for this form of the drug, especially in children [ 7 , 8 ]. The delivery of drugs via fast dissolving films is also an effective alternative for drugs with low bioavailability when administered by other routes [ 9 , 10 , 11 , 12 , 13 , 14 ]. Finally, ODFs are excellent systems for personalized therapy, especially for APIs with a narrow therapeutics index [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Orodispersible Films—Current State of the Art, Limitations, Advances and Future Perspectives

2023

View full text Add to dashboard Cite

Orodispersible Films (ODFs) are drug delivery systems manufactured with a wide range of methods on a big scale or for customized medicines and small-scale pharmacy. Both ODFs and their fabrication methods have certain limitations. Many pharmaceutical companies and academic research centers across the world cooperate in order to cope with these issues and also to find new formulations for a wide array of APIs what could make their work profitable for them and beneficial for patients as well. The number of pending patent applications and granted patents with their innovative approaches makes the progress in the manufacturing of ODFs unquestionable. The number of commercially available ODFs is still growing. However, some of them were discontinued and are no longer available on the markets. This review aims to summarize currently marketed ODFs and those withdrawn from sale and also provides an insight into recently published studies concerning orodispersible films, emphasizing of utilized APIs. The work also highlights the attempts of scientific communities to overcome ODF’s manufacturing methods limitations.

show abstract

Designing orodispersible films containing everolimus for enhanced compliance and bioavailability

Cited by 10 publications

References 26 publications

Quality by Design Approach for Optimization and Development of Orodispersible Films of Lornoxicam Inclusion Complexes

Quality by Design Approach for Optimization and Development of Orodispersible Films of Lornoxicam Inclusion Complexes

“Success Depends on Your Backbone”—About the Use of Polymers as Essential Materials Forming Orodispersible Films

Orodispersible Films—Current State of the Art, Limitations, Advances and Future Perspectives

Contact Info

Product

Resources

About