Designing Regenerative Bioadhesives for Tissue Repair and Regeneration

Li, Xuan; Liu, Yin; Liu, Shiyu; Li‐Jessen, Nicole Y. K.; Haglund, Lisbet; Huang, Baolin; Li, Jianyu

doi:10.1002/adtp.202300139

Cited by 6 publications

(3 citation statements)

References 138 publications

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“…The crystallites essentially act as knots within the network, ensuring significant dimensional stability and elastic properties of the hydrogels [47,52,53]. The values of the compressive elastic modulus between 14 kPa and 50 kPa make these hydrogels suitable for low-load-bearing tissue repair and regeneration [1,17,[54][55][56].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Poly(Vinyl Alcohol)/Bovine Serum Albumin Hybrid Hydrogels with Tunable Mechanical Properties

Bercea,

Plugariu,

Dinu

et al. 2023

Polymers

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In this study, a new strategy was adopted for obtaining polymer/protein hybrid hydrogels with shape stability and tunable mechanical or rheological characteristics by using non-toxic procedures. A chemical network was created using a poly(vinyl alcohol)(PVA)/bovine serum albumin (BSA) mixture in aqueous solution in the presence of genipin and reduced glutathione (GSH). Then, a second physical network was formed through PVA after applying freezing/thawing cycles. In addition, the protein macromolecules formed intermolecular disulfide bridges in the presence of GSH. In these conditions, multiple crosslinked networks were obtained, determining the strengthening and stiffening into relatively tough porous hydrogels with tunable viscoelasticity and a self-healing ability. A SEM analysis evidenced the formation of networks with interconnected pores of sizes between 20 μm and 50 μm. The mechanical or rheological investigations showed that the hydrogels’ strength and response in different conditions of deformation were influenced by the composition and crosslinking procedure. Thus, the dynamics of the hybrid hydrogels can be adjusted to mimic the viscoelastic properties of the native tissues. The dynamic water vapor-sorption ability, swelling behavior in an aqueous environment, and bioadhesive properties were also investigated and are discussed in this paper. The hybrid hydrogels with tunable viscoelasticity can be designed on request, and they are promising candidates for tissue engineering, bioinks, and wound dressing applications.

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Section: Mechanical Propertiesmentioning

confidence: 99%

Poly(Vinyl Alcohol)/Bovine Serum Albumin Hybrid Hydrogels with Tunable Mechanical Properties

Bercea,

Plugariu,

Dinu

et al. 2023

Polymers

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show abstract

“…Another example from our lab is a tissue-mimetic hybrid bioadhesive, combining a cell-compatible alginate glue to fill the NP cavity and an alginate–polyacrylamide tough hydrogel to close the AF defect. A combination of in vitro and ex vivo testing results shows the efficacy of the hybrid bioadhesive in restoring mechanical function and achieving compatibility with cells, exemplifying the regenerative capacity and repair efficacy of bioadhesives …”

Section: Introductionmentioning

confidence: 99%

“…shows the efficacy of the hybrid bioadhesive in restoring mechanical function and achieving compatibility with cells, exemplifying the regenerative capacity and repair efficacy of bioadhesives. 12 Despite the progress, existing hydrogel bioadhesives cannot meet the requirements of AF repair. First, the intrinsic stiffness and strength of hydrogel bioadhesives are many orders of magnitude lower than those of AF tissues.…”

Section: Introductionmentioning

confidence: 99%

Composite Hydrogel Sealants for Annulus Fibrosus Repair

Li,

Huo,

et al. 2024

ACS Biomater. Sci. Eng.

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Intervertebral disc (IVD) herniation is a leading cause of disability and lower back pain, causing enormous socioeconomic burdens. The standard of care for disc herniation is nucleotomy, which alleviates pain but does not repair the annulus fibrosus (AF) defect nor recover the biomechanical function of the disc. Existing bioadhesives for AF repair are limited by insufficient adhesion and significant mechanical and geometrical mismatch with the AF tissue, resulting in the recurrence of protrusion or detachment of bioadhesives. Here, we report a composite hydrogel sealant constructed from a composite of a three-dimensional (3D)-printed thermoplastic polyurethane (TPU) mesh and tough hydrogel. We tailored the fiber angle and volume fraction of the TPU mesh design to match the angle-ply structure and mechanical properties of native AF. Also, we proposed and tested three types of geometrical design of the composite hydrogel sealant to match the defect shape and size. Our results show that the sealant could mimic native AF in terms of the elastic modulus, flexural modulus, and fracture toughness and form strong adhesion with the human AF tissue. The bovine IVD tests show the effectiveness of the composite hydrogel sealant for AF repair and biomechanics recovery and for preventing herniation with its heightened stiffness and superior adhesion. By harnessing the combined capabilities of 3D printing and bioadhesives, these composite hydrogel sealants demonstrate promising potential for diverse applications in tissue repair and regeneration.

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Engineered Bio‐Based Hydrogels for Cancer Immunotherapy

Peng,

Liang,

Meng

et al. 2024

Advanced Materials

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Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy and severe immune‐related side effects are frequently encountered, especially in solid tumors. Hydrogels, a class of versatile materials featuring well‐hydrated structures widely used in biomedicine, offer a promising platform for encapsulating and releasing small molecule drugs, biomacromolecules, and cells in a controlled manner. Immunomodulatory hydrogels present unique capability for augmenting immune activation and mitigating systemic toxicity through encapsulation of multiple components and localized administration. Notably, hydrogels based on biopolymers have gained significant interest owing to their biocompatibility, environmental friendliness, and ease of production. This review delves into the recent advances in bio‐based hydrogels in cancer immunotherapy and synergistic combinatorial approaches, highlighting their diverse applications. We anticipate that this review will guide the rational design of hydrogels in the field of cancer immunotherapy, fostering clinical translation and ultimately benefiting patients.This article is protected by copyright. All rights reserved

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Designing Regenerative Bioadhesives for Tissue Repair and Regeneration

Cited by 6 publications

References 138 publications

Poly(Vinyl Alcohol)/Bovine Serum Albumin Hybrid Hydrogels with Tunable Mechanical Properties

Poly(Vinyl Alcohol)/Bovine Serum Albumin Hybrid Hydrogels with Tunable Mechanical Properties

Composite Hydrogel Sealants for Annulus Fibrosus Repair

Engineered Bio‐Based Hydrogels for Cancer Immunotherapy

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