Designing Salvigenin –loaded mPEG-b-PLGA @Fe3O4 nanoparticles system for improvement of Salvigenin anti-cancer effects on the breast cancer cells, an in vitro study

Near‐Infrared Emission‐Cyanine 5.5 and Doxorubicin Loaded Magnetite Nanoparticles for Dual In Vivo Magnetic Resonance and Biodistribution Imaging

“…The XRD patterns of the PLA‐TPGS‐Fe 3 O 4 ‐Cyanine 5.5 and PLA‐TPGS‐Fe 3 O 4 ‐Cyanine 5.5‐Dox nanoparticles showed no shifting in position but broadened characteristic peaks, indicating the successful encapsulation of APTES and PLA‐TPGS copolymer, the loading of Cyanine 5.5 and Doxorubicin without degrading the core magnetite. Other studies have also shown similar results in which Fe 3 O 4 NPs were coated with PEG polymers, [71] dextran, [72] mPEG‐b‐PLGA [73] or attached with fluorescent agents such as CdTe core‐type quantum dots [74]…”

“…The calculated mean crystallite diameter was 9 nm, which is similar to the size observed by the TEM images above. It also revealed the single-crystal nature and high crystallinity of [71] dextran, [72] mPEG-b-PLGA [73] or attached with fluorescent agents such as CdTe core-type quantum dots. [74] The magnetization curves for all samples are shown in Figure 7B.…”

Determination of fingerprints contents of different extracts and parts of six endemic Salvia taxa by GC–MS: Source species for valuable compounds with drug or drug potential

“…The 12‐demethylmulticauline compound, which is present in the SCCRE‐6 sample, has an antituberculous (Topcu et al, 2017) activity potential. Salvigenin, which is present in high concentrations in SRWE‐6, SSWC‐5 and SRWC‐5 samples, has trypanocidal (Frezza et al, 2020), cyclooxygenase inhibitor, antioxidant (Topcu et al, 2017), anticancer (Mansourizadeh et al, 2020), antidepressant, anxiolytic and antinociceptive (Abdelhalim et al, 2015) activities. The high percentages of lupeol and its derivative compounds in the SRWE‐6 sample have numerous biological activity potentials, such as anthelmintic (Flota‐Burgos et al, 2020), wound healing (Beserra et al, 2020), immunomodulatory (Wahdaningsih et al, 2020), antiproliferative (Landim et al, 2019), anticancer (Babu et al, 2019), anti‐inflammatory, antivirus and antidiabetes (Xu et al, 2018).…”

Superparamagnetic Artificial Cells PLGA-Fe3O4 Micro/Nanocapsules for Cancer Targeted Delivery

“…The Encapsulated Drug and the Corresponding Reference Lung cancer Tetrandrine [106,107], Doxorubicin [108], Silibinin [111], Curcumin [112], Silibinin + Metformin [113] Breast cancer Methotrexate [114,115], Doxorubicin [116,117], Salvigenin [118], Gemcitabine [119,120], Paclitaxel + Transferrin [121], Docetaxel [122], Vitamin C [123], Olaparib [124], Chlorin E6 [125], Indocyanine green + Zoledronic acid [126], Glucose oxidase [127] Glioblastoma Paclitaxel [128], Doxorubicin [129], Lenalidomide [ Poly(ethylene glycol) (PEG) can escape immune recognition, prevent macrophage attachment, enhance retention time for drug delivery [139,140], and minimize the nonspecific uptake in normal tissues [141]. Thus, the magnetic PLGA-PEG nanoparticle was used to fabricate a magnetic nanocarrier to deliver silibinin (Sil) [111], curcumin (Cur) [112], and co-deliver silibinin (Sil) with metformin (Met) [113].…”

“…Breast cancer is one of the most common forms of malignant tumors among women worldwide and poses a severe threat to their well-being [142]. Several drugs for breast cancer and Fe 3 O 4 NPs were co-encapsulated into PLGA or PLGA-PEG shells to form the magnetic nanocapsules to carry the drugs to the breast cancer cells, such as Methotrexate (MTX) [114,115], Doxorubicin (DOX) [116,117], Salvigenin (Sal) [118], Gemcitabine (Gem) [119,120], Paclitaxel (PTX) and Transferrin (Tf) [121], Docetaxel (DTX) [122], Vitamin C (Vc) [123], Olaparib (Olb) [124], and Chlorin E6 (Ce6) [125].…”