“…Khoshvaght-Aliabadi et al [46][47][48] studied the effect of nanofluid in minichannels with different cross-section configurations, including square and rectangular types, on heat transfer coefficient and pressure drop. Meanwhile, CFD simulations were used in SPHE studies to validate the analytical calculations 8,13,49 or to assess the experimental results. 50 In addition, studying the effects of different nanofluids on thermal and hydraulic performance improvement were conducted in SPHEs recently by Bahiraei et al, [51][52][53] Mazaheri and Bahiraei, 54 Rostami et al, 55 and Khodabandeh et al 56 According to previous research available on the thermal design of SPHEs, few researchers tried to propose a general optimal design algorithm for the SPHEs to consider all aspects of design factors including thermal, hydraulic, geometric, and economic parameters.…”