This paper outlines opportunities and challenges for building missile seekers with the Sensor Open Systems Architecture™ (SOSA) Technical Standard, Edition 2.0, Version 2 (Snapshot 2). In Section 1, two missile seeker instance architectures using the SOSA Technical Architecture are described, one for Electro-Optical/Infrared (EO/IR) and one for Radio Detection and Ranging (RADAR). Opportunities within the logical signal processing chain, including module functions, inter-module interactions, and messaging sets are discussed in Sections 2, 3, 4, and 5. Section 6 addresses the potential challenges in the physical layer due Size, Weight, and Power (SWaP) constraints on missile systems. In Section 7, some opportunities to support swappable seekers within the Modular Open Systems Approach (MOSA) ecosystem are outlined. The findings of this effort are summarized in the conclusion section.