Desired properties of polymeric hydrogel vitreous substitute

Qu, Sheng; Tang, Yi; Ning, Zichao; Zhou, Yanjie; Wu, Hong

doi:10.1016/j.biopha.2024.116154

Cited by 3 publications

(3 citation statements)

References 134 publications

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“…The ideal candidate biomaterials can bridge tissue damage and improve regeneration by enhancing new natural tissue regeneration (Xue et al, 2021). Simultaneously, they are also required to demonstrate excellent biocompatible, tunable mechanical properties and biodegradation as they degrade gradually during tissue repair (Wu D. et al, 2024;Zhou H. et al, 2024;Vaidya et al, 2024). To date, a variety of natural and synthetic biomaterials have been applied in an attempt to simulate ECM of the natural bone tissue (Xu et al, 2023;Sung et al, 2024;Yoon et al, 2024).…”

Section: Application Of Exogenous Stimulusresponsive In Situ Gelling ...mentioning

confidence: 99%

“…Therefore, novel hydrogel biomaterials with smart properties to promote clinical practices in biomedicine and tissue regeneration engineering are needed. Smart responsive in situ hydrogels are extensively applied in bone tissue engineering (Ali et al, 2024;Asadi et al, 2024;Zhou H. et al, 2024;Garg et al, 2024). This strategy can guide hydrogels to adapt to diverse shapes and depths of bone defects, which will promote integration with bone tissue.…”

Section: Application Of Exogenous Stimulusresponsive In Situ Gelling ...mentioning

confidence: 99%

“…Usually, those chemical reactions promote covalent linkage in hydrogels through chemical crosslinking, such as click chemistry (e.g., Diels–Alder reaction, Michael addition reaction, or thiol–Michael addition reaction). In the assembly of hydrophilic polymers, those deterministic groups, such as COOH-, OH-, and NH 2 -, are utilized to construct a hydrogel system via a covalent bond between amine-carboxylate and a Schiff alkali or isocyanate-OH/NH 2 ( Liu H. et al, 2023 ; Wang X. et al, 2024 ; Qu et al, 2024 ).…”

Section: Application Of Endogenous Stimulus-responsive In S...mentioning

confidence: 99%

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Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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Section: Application Of Exogenous Stimulusresponsive In Situ Gelling ...mentioning

confidence: 99%

Section: Application Of Exogenous Stimulusresponsive In Situ Gelling ...mentioning

confidence: 99%

Section: Application Of Endogenous Stimulus-responsive In S...mentioning

confidence: 99%

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Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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Injectable cross-linked hyaluronic acid hydrogels with epigallocatechin gallate loading as vitreous substitutes

Chen,

Tai,

Hsieh

et al. 2024

International Journal of Biological Macromolecules

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Contributions of Medical Greenhouse Gases to Climate Change and Their Possible Alternatives

Wang,

DasSarma

2024

IJERPH

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Considerable attention has recently been given to the contribution of the greenhouse gas (GHG) emissions of the healthcare sector to climate change. GHGs used in medical practice are regularly released into the atmosphere and contribute to elevations in global temperatures that produce detrimental effects on the environment and human health. Consequently, a comprehensive assessment of their global warming potential over 100 years (GWP) characteristics, and clinical uses, many of which have evaded scrutiny from policy makers due to their medical necessity, is needed. Of major interest are volatile anesthetics, analgesics, and inhalers, as well as fluorinated gases used as tamponades in retinal detachment surgery. In this review, we conducted a literature search from July to September 2024 on medical greenhouse gases and calculated estimates of these gases’ GHG emissions in metric tons CO2 equivalent (MTCO2e) and their relative GWP. Notably, the anesthetics desflurane and nitrous oxide contribute the most emissions out of the major medical GHGs, equivalent to driving 12 million gasoline-powered cars annually in the US. Retinal tamponade gases have markedly high GWP up to 23,500 times compared to CO2 and long atmospheric lifetimes up to 10,000 years, thus bearing the potential to contribute to climate change in the long term. This review provides the basis for discussions on examining the environmental impacts of medical gases with high GWP, determining whether alternatives may be available, and reducing emissions while maintaining or even improving patient care.

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Desired properties of polymeric hydrogel vitreous substitute

Cited by 3 publications

References 134 publications

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Injectable cross-linked hyaluronic acid hydrogels with epigallocatechin gallate loading as vitreous substitutes

Contributions of Medical Greenhouse Gases to Climate Change and Their Possible Alternatives

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