Desloratadine-Eudragit^® RS100 Nanoparticles: Formulation and Characterization

Abstract

ÖZAmaç: Bu çalışmanın amacı, Desloratadin-Eudragit ® RS100 nanopartiküllerini formüle etmek ve hazırlanan nanopartiküllerin özelliklerini araştırmaktır. Gereç ve Yöntemler: Nanopartiküller püskürterek kurutma yöntemi ile hazırlanmış ve miktar tayini yüksek basınçlı sıvı kromatografisi (YBSK) yöntemi ile yapılmıştır. Bulgular: Desloratadin (DL) başarıyla polimere yüklenmiş ve geliştirilen YBSK yönteminin doğrusal, tekrarlanabilir, hassas, doğru, spesifik ve selektif olduğu bulunmuştur. Önerilen püskürterek kurutma yöntemi, DL içeren nanopartikül preparatının hazırlanmasında başarı ile kullanılmıştır. Nanopartiküllerin karakterizasyonu partikül boyutu, zeta potansiyel, morfoloji, polidispersite indeksi, katı hal karakterizasyonları ve etkin madde salımı dahil olmak üzere yapılmıştır. DL yüklü nanopartiküllerin in vitro salım çalışmaları, simüle edilmiş barsak vasatında (pH 7.4) incelenmiştir. Nanopartikül formülasyonlarından DL'nin in vitro salımı, Korsemeyer-Peppas modeline uymaktadır. Sonuç: DL miktar tayini için YBSK yöntemi geliştirilmiştir. Önerilen püskürterek kurutma yöntemi, DL içeren nanopartikül preparatına başarıyla uygulanmıştır. Ayrıca, tüm nanopartiküllerin ve etkin maddenin salım çalışmaları karşılaştırmalı olarak incelenmiştir. Bu nedenle, DL yüklü nanopartiküllerin etkin madde için umut verici bir ilaç taşıyıcı sistem olduğu sonucuna varılabilir. Anahtar kelimeler: Desloratadin, Eudragit ® RS100, YBSK, nanopartikül Objectives:The objective of the present study was to formulate Desloratadine-Eudragit ® RS100 nanoparticles and investigate the characteristics of the prepared nanoparticles. Materials and Methods: The nanoparticles were prepared by spray drying method and the quantification of desloratadine (DL) was carried out with a high performance liquid chromatography (HPLC) method. Results: DL was successfully loaded to polymer and the developed HPLC method was found to be linear, reproducible, precise, accurate, specific and selective. Characterization of the nanoparticles including entrapment efficiency, particle size, zeta potential, morphology, polidispersity index, solid state characterizations and drug release was performed. In vitro release studies of DL loaded nanoparticles were also examined in the simulated intestinal fluid (pH 7.4). In vitro release of DL from nanoparticle formulations followed Korsemeyer-Peppas model. Conclusion: A validated HPLC method was developed for the determination of DL. Proposed spray drying method can be successfully applicable to the nanoparticle preparation containing DL. In addition, the release studies of all nanoparticles and active substance have been studied comparatively. Hence, it could be concluded that DL loaded nanoparticles seem to be a promising drug delivery system for the active agent.

Nanocapsules containing Saussurea lappa essential oil: Formulation, characterization, antidiabetic, anti-cholinesterase and anti-inflammatory potentials

“…Fourier transform infrared spectroscopy analysis was carried out to investigate the chemical interaction between SL-EO and PMMA. Apparently, drug-polymer interaction 19 resulted in changes in FTIR spectra (Yenilmez, 2017). The FTIR patterns of SL-EO, PMMA and loaded-NP were shown in Fig.…”

Bioresponsive Hybrid Nanofibers Enable Controlled Drug Delivery through Glass Transition Switching at Physiological Temperature

“…13 To explore the possibility of the desired drug release at 37 °C, polymer blends of ERS and PMMA were subsequently investigated. Here ERS, a biomaterial widely applied as a polymer carrier of active substances to the site of interest, 29 and PMMA, a broadly utilized biomaterial with low toxicity, 30 were selected. OCT, an effective antimicrobial often used as a skin antiseptic, 28 was chosen as the model drug.…”

Host-guest inclusion complex of desloratadine with 2-(hydroxy)propyl-?-cyclodextrin (HP-?-CD): Preparation, binding behaviors and dissolution properties

“…The spectra also showed alkene [C=C stretching (conjugated)] at 1610-1640 cm -1 , imines (R2C=N-R stretching) at 1640-1690 cm -1 , aromatic C-H (stretching) at 3000-3020 cm -1 and alkanes (C-H stretching) at 2980-2850 cm -1 [34]. Other peaks observed at 1176 cm -1 and 779 cm -1 corresponded to C-N and C-Cl stretching, respectively and given in Figure 5 [35].…”