Desmodium molliculum (Kunth) DC (Fabaceae); Perfil etnobotánico, fitoquímico y farmacológico de una planta andina peruana

Abstract

Antecedentes: Desmodium molliculum conocida comúnmente como "pie de perro", "pata de perro", "chancas de comida", "muña" o "manayupa" es una planta andina peruana que crece entre los 1000-3500 msnm, es una hierba rastrera perteneciente al orden Fabales, familia Fabaceae y género Desmodium. Es originaria de los andes peruanos, sin embargo, se distribuye desde México a Sudamérica. El propósito de esta revisión es proporcionar información completa sobre la botánica, usos tradicionales, fitoquímica, investigación farmacológica y toxicología de Desmodium molliculum.Métodos: La búsqueda de información para la elaboración de esta revisión fue realizada en los motores de búsqueda y base de datos Scielo, PubMed, Scopus y Google Académico, los criterios de inclusión de la información fueron artículos originales y de revisión, tesis de grado y postgrado, no se descartaron resultados por año de publicación, los idiomas se redujeron a Español e Inglés.Resultados: Desmodium molliculum ha exhibido un amplio espectro de actividades farmacológicas como actividades cicatrizantes, antiasmáticas, antiinflamatorias, hepatoprotectoras, antibacterianas, anticonceptivas, antioxidantes entre otras.Conclusiones: Se concluye que desde un punto de vista etnofarmacológico, es necesario investigar los mecanismos bioquímicos y fisiológicos involucrados en los diferentes efectos biológicos exhibidos por esta especie, especialmente las acciones inmunomoduladoras, relajante del músculo liso y anticonceptivas de Desmodium molliculum. También es necesario buscar metabolitos secundarios individuales responsables de estas acciones y poder estudiar los mecanismos de acción, la biodisponibilidad, la farmacocinética y las vías fisiológicas con suficiente detalle.

Functional Properties and Acceptability of Potentially Medicinal Tea Infusions Based on Equisetum arvense, Desmodium molliculum, and Mentha piperita

“…One of them is the species Equisetum arvense , commonly called “horsetail,” a widely used for its antioxidant, antimicrobial, anti-inflammatory, antidiabetic, and other benefits ( Al-Snafi, 2017 ), as well as its cytotoxic and antigenotoxic effects by activating antioxidant transcription in the promoter regions of genes that induce oxidative stress, limiting cancerous proliferation ( Batir-Marin et al, 2021 ; Dormousoglou et al, 2022 ), with diuretic, antiprostatic, and renal properties thanks to flavonoids and potassium salts, which also confer demineralizing properties and contribute to the maintenance of collagen by increasing tissue elasticity ( Batir-Marin et al, 2021 ; Boeing et al, 2021 ). Desmodium molliculum also known as “dog’s paw” or “Manayupa,” is an intriguing plant with multifunctional properties very similar to those of E. arvense , as demonstrated by studies demonstrating its high healing capacity, antiasthmatic, anti-inflammatory, antibacterial, contraceptive, antioxidant, and hepatoprotective, effects, associated with alleviating fevers, relieving inflammation, and other diseases ( Boeing et al, 2021 ), associated with alleviating fevers, dysentery, liver diseases, wound healing, ulcers, eye diseases, abdominal tumors, asthma, nasal polyps, menstrual disorders, colds, and kidney problems, among many others ( Ayala-Mata et al, 2020 ; Olascuaga-Castillo et al, 2020 ; Joshi et al, 2023 ). A highly appreciated species is Mentha piperita , commonly known as “peppermint,” a species that has been shown to have good ferrous ion chelating capacity ( Chan et al, 2010 ) and to be widely used as a folk remedy to treat irritable bowel syndrome, indigestion, flatulence, nausea, vomiting, diarrhea, and bronchopulmonary problems, due to the phenolic constituents in its leaves, thanks to the leaves, thanks to the phenolic compounds in the phenolic compounds in the leaves such as rosmarinic acid and various flavonoids, such as eriocitrin, luteolin, and hesperidin that trigger these effects, as well as its energetic aroma and refreshing taste used for pharmacological and food industries ( McKay and Blumberg, 2006 ; Salehi et al, 2018 ; Mahendran and Rahman, 2020 ).…”

Phytochemical Screening and Antiinflammatory Activity of the Extract from the Leaves of Desmodium molliculum (Kunth) DC (Fabaceae) in Rats with Acute Inflammation

“…Peruvian traditional medicine has used plant resources from pre-Columbian cultures to the present day, and the Desmodium genus is no exception. 1 It has been used in traditional medicine for its diverse phytotherapeutic benefits, 2 such as its antirheumatic, 3 balsamic, 4 diaphoretic, 5 asthmatic crisis treatment, 6 menstrual pain relief 7 and its anti-inflammatory properties. 5,6 Desmodium molliculum (Kunth) DC, also known as "dog's paw" or "ma nayupa", is a perennial herbaceous species belonging to the Fabaceae family, native to Peru and Latin America, which grows predominantly in the Andean region and reaches a height of approximately 50 cm.…”