Desmoid Fibromatosis of the Lower Abdominal Wall in Irrua Nigeria

Abstract

Desmoid fibromatosis (desmoid tumors) is rare tumors. It can occur as intra-abdominal, extraabdominal, or abdominal wall tumor depending on the site. The abdominal wall type is usually sporadic, but few have been associated with familial adenomatous polyposis. They are commonly seen in young females who are pregnant with a history of the previous cesarean section scar or within the 1st year of the last childbirth. There is an association between this tumor, presence of estrogen receptors, and abdominal trauma. We present a 29-year-old Nigerian woman with fungating lower abdominal wall tumor. This tumor is rare, a high index of suspicion will be very important in making the diagnosis.

Possible involvement of cyclooxygenase-2 in the recurrence of desmoid fibromatosis: case series and mini-review of the literature

“…Although it is non-metastatic, morbidity due to local complications and the local recurrence rate after resection is high, ranging from 20%-40% [2]; It arises in numerous locations, but most often in the limbs, waist, scapula, and the trunk, including the abdominal cavity [3]. DF accounts for approximately 0.03% of all soft tissue tumors [4].…”

“…In sporadically arising cases, approximately 7.5% of DF patients have a history of Familial Adenomatous Polyposis (FAP) and have an 800-fold increased risk of developing DF compared to the general population [5]. DF affects a wide range of ages, but it is most common among those between 10 and 40 y of age [1][2][3]. In the paediatric population, it arises equally in both sexes, and is predominantly abdominal [2,3].…”

“…DF affects a wide range of ages, but it is most common among those between 10 and 40 y of age [1][2][3]. In the paediatric population, it arises equally in both sexes, and is predominantly abdominal [2,3]. Between puberty and 40 y old, tumors are most common in women, and predominantly arise in the abdominal wall [6,7].…”

“…Several factors indicate the role of estrogen in its development, including the high incidence of pregnant women who develop the condition, and disease regression or stabilization after estrogen blockade [8]. Several studies have demonstrated estrogen receptor (ERβ) positivity in up to 90% of neoplasms [2,9,10]. DF has also been reported to occur at sites of previous surgery or blunt trauma [2,11,12].…”

“…Several studies have demonstrated estrogen receptor (ERβ) positivity in up to 90% of neoplasms [2,9,10]. DF has also been reported to occur at sites of previous surgery or blunt trauma [2,11,12]. Sporadic cases show a mutation in the β-catenin gene on 3p21, resulting in overexpression of β-catenin in the nucleus [13,14].…”