Desmoid Tumor: Prognostic Factors and Outcome After Surgery, Radiation Therapy, or Combined Surgery and Radiation Therapy

Ballo, Matthew T.; Zagars, Gunar K.; Pollack, Alan; Pisters, Peter W.T.; Pollock, R

doi:10.1200/jco.1999.17.1.158

Cited by 456 publications

(412 citation statements)

References 32 publications

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“…Local infiltrative growth and tissue invasion can result in pain, deformity, functional impairment, and death when vital organs are involved. 14,16,17 The attendant morbidity and mortality from these tumors is highly sitedependent. Intraabdominal desmoid infiltration of vital organs reportedly leads to a 10-year mortality rate of approximately 37%.…”

Section: Results Both Patients Demonstrated Ongoing Radiographic Andmentioning

confidence: 99%

“…19 Adjuvant radiotherapy has been shown to reduce recurrence rates by as much as 50%, and may offset the negative prognostic impact of positive surgical margins, allowing for a surgical approach that balances local control with a significant impact on long-term function and morbidity. 16 Despite having a relatively high local failure rate, surgical resection of extraabdominal desmoid tumors, with adjuvant radiotherapy for a positive surgical margin, remains the standard approach. Although primary radiotherapy can produce local control rates that are comparable to those achieved with surgery alone, 25 the risk of secondary malignancy and the potential for postradiation fibrosis make surgery the initial option of choice if a negative surgical margin resection is anticipated.…”

Section: Results Both Patients Demonstrated Ongoing Radiographic Andmentioning

confidence: 99%

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Response of extraabdominal desmoid tumors to therapy with imatinib mesylate

Mace

Biermann

Sondak

et al. 2002

Cancer

182

110

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BACKGROUNDDesmoid tumor represents a rare monoclonal neoplasm arising from deep musculoaponeurotic structures and may occur sporadically or in association with the familial adenomatous polyposis and Gardner syndromes. Desmoid tumors do not appear to demonstrate metastatic potential; however, local infiltrative growth results in significant morbidity and potential mortality. Although the delineation of optimal therapy for desmoid tumors has been confounded by several factors, surgical resection with adjuvant radiotherapy for a positive surgical margin remains the standard approach. Responses have been demonstrated to nonsteroidal antiinflammatory agents, antiestrogen compounds, and a variety of other agents in small series. Imatinib mesylate appears to demonstrate inhibitory activity against multiple class 3 receptor tyrosine kinases, including platelet‐derived growth factor receptor (PDGFR)‐α and PDGFR‐β, as well as c‐kit.METHODSThe authors performed immunohistochemical and qualitative real‐time polymerase chain reaction analysis on nine desmoid tumor specimens that demonstrated consistent positivity for c‐kit as well as PDGFR‐α and PDGFR‐β. At the time of last follow‐up, 2 patients had received therapy with imatinib mesylate at a dose of 400 mg twice daily.RESULTSBoth patients demonstrated ongoing radiographic and clinical responses with a duration of 9 months and 11 months, respectively.CONCLUSIONSImatinib mesylate has been reported to have activity against desmoid tumor, most likely because of c‐kit and PDGFR receptor tyrosine kinase activity inhibition, and warrants further study. The relative novelty of this agent and the lack of long‐term toxicity data should prompt its use only in the salvage setting in which established local and systemic approaches fail to control disease. In addition, the use of imatinib mesylate in the treatment of this neoplasm preferably should be in the context of a formal prospective clinical trial. Cancer 2002;95:2373–9. © 2002 American Cancer Society.DOI 10.1002/cncr.11029

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Section: Results Both Patients Demonstrated Ongoing Radiographic Andmentioning

confidence: 99%

Section: Results Both Patients Demonstrated Ongoing Radiographic Andmentioning

confidence: 99%

Response of extraabdominal desmoid tumors to therapy with imatinib mesylate

Mace

Biermann

Sondak

et al. 2002

Cancer

182

110

View full text Add to dashboard Cite

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“…Nevertheless, it must be noted that the importance of positive margin status to local recurrence rates, is still a matter of debate. In contrast to other published series [2,10], a study by Gronchi et al showed that presence of microscopic disease did not affect long-term disease-free survival in patients with primary presentation of extra-abdominal desmoid tumors [11]. Primary RT is an appropriate alternative for patients who are not good surgical candidates [12].…”

Section: Discussionmentioning

confidence: 97%

“…Given the benign nature of these tumors, treatment strategies aim at achieving local control while preserving proper function and providing with an adequate cosmetic result [4]. When medically and technically feasible, complete resection of the tumor with negative microscopic margins is the first-line treatment [10]. Nevertheless, it must be noted that the importance of positive margin status to local recurrence rates, is still a matter of debate.…”

Section: Discussionmentioning

confidence: 99%

Desmoid tumor of the supraclavicular region: a case report

Koukoutsis

Παππάς

Karanikas

et al. 2009

Cases J

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Desmoid tumors are rare, benign fibroblastic tumors that are locally infiltrative and can cause extensive morbidity by destruction of adjacent vital structures. Due to the rarity of these tumors, evidence regarding optimal treatment protocols is drawn from case reports and single-arm series with small patient numbers. We report a case of a patient with a desmoid tumor of the left supraclavicular region that was diagnosed and treated in our department and a review of the current literature.

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“…15,17,21 Wide surgical excision offers the best chance of avoiding recurrence but is difficult to achieve because of the infiltrative nature of desmoid tumors. 2 Spontaneous disappearance of desmoid tumors has occasionally been reported. 5,11 In the current report, the owner declined treatment.…”

mentioning

confidence: 99%

Fibromatosis in a Young Bernese Mountain Dog: Clinical, Imaging, and Histopathological Findings

et al. 2009

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Abstract. A young, intact, male Bernese Mountain Dog was presented to the animal hospital for lameness and diffuse thickening of the soft tissue in the right hind limb. Magnetic resonance imaging revealed multiple, multilobular, space-occupying lesions within and between the muscles of the right femur. Biopsies taken from the lesions revealed an infiltrative mass composed mainly of collagen fibers and a low density of benignappearing fibroblasts. These findings were compatible with a diagnosis of a fibromatosis. Taking the age of onset into account, infantile fibromatosis was most likely. A deep fibromatosis, similar to that seen in adults, could not be excluded based on histology.

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Desmoid Tumor: Prognostic Factors and Outcome After Surgery, Radiation Therapy, or Combined Surgery and Radiation Therapy

Cited by 456 publications

References 32 publications

Response of extraabdominal desmoid tumors to therapy with imatinib mesylate

Response of extraabdominal desmoid tumors to therapy with imatinib mesylate

Desmoid tumor of the supraclavicular region: a case report

Fibromatosis in a Young Bernese Mountain Dog: Clinical, Imaging, and Histopathological Findings

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