Desmoid tumors in Gardner syndrome: use of computed tomography

Magid, Donna; Fishman, E K; Jones, Bronwyn; Hoover, HC; Feinstein, Richard S.; Siegelman, SS

doi:10.2214/ajr.142.6.1141

Cited by 41 publications

(13 citation statements)

References 5 publications

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“…Mesenteric DF, most commonly encountered with FAP in Gardner syndrome, is typically seen at CT as a soft-tissue mass with radiating spicules extending into the adjacent mesenteric fat (20). CT is the most commonly used imaging modality for the diagnosis and follow-up of patients with intra-abdominal DF and for the detection of associated complications such as small bowel obstruction (21).…”

Section: Imaging Features At Ctmentioning

confidence: 99%

Role of Imaging in Management of Desmoid-type Fibromatosis: A Primer for Radiologists

Braschi‐Amirfarzan¹,

Keraliya²,

Krajewski³

et al. 2016

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Desmoid-type fibromatosis (DF) is a locally aggressive fibroblastic neoplasm that has variable clinical and biologic behaviors ranging from indolent tumors that can undergo spontaneous regression to aggressive tumors with a tendency toward local invasion and recurrence. The management of DF has evolved considerably in the last decade from aggressive first-line surgery and radiation therapy to systemic treatment (chemotherapy, hormonal therapy, and targeted therapy) and symptomatic local control (surgery and radiation therapy). Imaging plays an important role in each of these treatment settings. In surgical candidates, computed tomography (CT) and magnetic resonance (MR) imaging are the modalities of choice for assessing resectability and surgical planning. For evaluating recurrence, MR imaging is the modality of choice for extra-abdominal recurrence, whereas CT is the preferred modality for intra-abdominal recurrence. Signal intensity changes at MR imaging can be used to monitor the biologic behavior of certain DFs chosen for expectant management. Response to systemic treatment with anti-inflammatory agents, hormonal therapy (eg, tamoxifen), cytotoxic chemotherapy (eg, doxorubicin, vinblastine, methotrexate), and targeted therapy (eg, sorafenib), as well as to radiation therapy, can be assessed at CT by monitoring size and attenuation changes or at MR imaging by monitoring size, T2 signal intensity, and degree of enhancement. Several patterns of response can be seen at imaging. Imaging also helps in detecting complications associated with systemic therapy and radiation therapy. (©)RSNA, 2016.

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Section: Imaging Features At Ctmentioning

confidence: 99%

Role of Imaging in Management of Desmoid-type Fibromatosis: A Primer for Radiologists

Braschi‐Amirfarzan¹,

Keraliya²,

Krajewski³

et al. 2016

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130

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“…CT is useful in estimating the size of the tumor, in following response to therapy, and in preoperative planning and typically shows homogeneous soft-tissue density (approximately 4 0 -6 0 HU) [1]. These tumors enhance variably with contrast material, with extraabdominal tumors demonstrating the greatest propensity to enhance mesenteric tumors the least [1].…”

Section: Discussionmentioning

confidence: 99%

“…These tumors enhance variably with contrast material, with extraabdominal tumors demonstrating the greatest propensity to enhance mesenteric tumors the least [1]. Angiography characteristically reveals neovascularity at extraabdominal sites [9,10].…”

Section: Discussionmentioning

confidence: 99%

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Abscess formation in desmoid tumors of Gardner's syndrome and percutaneous drainage: A report of three cases

Maldjian

Mitty

Garten

et al. 1995

Cardiovasc Intervent Radiol

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“…CT is currently the standard technique for evaluating suspected IAD in FAP [11]. Intuitively, MRI may provide better assessment of desmoids, being the modality of choice in the diagnosis and prognostication of other benign and malignant soft-tissue tumours, owing to its superior contrast-to-noise ratio [12].…”

mentioning

confidence: 99%

Imaging assessment of desmoid tumours in familial adenomatous polyposis: is state-of-the-art 1.5 T MRI better than 64-MDCT?

Hansmann¹,

Bhandari²,

Gupta³

et al. 2012

BJR

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Desmoid tumors in Gardner syndrome: use of computed tomography

Cited by 41 publications

References 5 publications

Role of Imaging in Management of Desmoid-type Fibromatosis: A Primer for Radiologists

Role of Imaging in Management of Desmoid-type Fibromatosis: A Primer for Radiologists

Abscess formation in desmoid tumors of Gardner's syndrome and percutaneous drainage: A report of three cases

Imaging assessment of desmoid tumours in familial adenomatous polyposis: is state-of-the-art 1.5 T MRI better than 64-MDCT?

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