Desmoid tumorsA clinical review of 30 patients with more than 20 years’ follow-up

Dalén, B P Mikael; Bergh, Peter; Gunterberg, Björn

doi:10.1080/00016470310017785

Cited by 73 publications

(31 citation statements)

References 20 publications

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“…Recurrence rates have varied between 15 and 77% [4,12,17,19]. In our series, 25% of the patients had a recurrence with the majority of the recurrences occurring within the first 2 years following surgery.…”

Section: Discussionmentioning

confidence: 59%

“…However, they lack the cytological features of malignancy and have essentially no metastatic potential [5,9,11,16]. Depending on the site and type of resection, the reported local recurrence rates range from 15 to 77% [4,12,17,19,20,22]. Traditionally, desmoid tumours have been managed with surgery with wide local excision being the preferred treatment [3,10,16,19].…”

Section: Introductionmentioning

confidence: 99%

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The management of extra-abdominal desmoid tumours

Duggal

Dickinson

Sommerville

et al. 2004

International Orthopaedics (SICOT)

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We performed a retrospective analysis of 35 cases of desmoid tumours (aggressive fibromatoses) that underwent treatment at our institutions between 1987 and 2002. The purpose was to evaluate the rate of local recurrence of desmoid tumours treated with surgical excision, to assess the impact of surgical margins on local recurrence and to define the role of radiotherapy in the treatment. Nine patients experienced a recurrence at an average of 16 months after initial treatment. Seven of the 15 patients with a less-than-wide margin had a local recurrence. Comparatively, only two of the 20 patients with a wide margin had a local recurrence. Thirty-three of the 35 patients were disease free at the last follow-up. We recommend wide excision with clear margins whenever possible. Marginal resections are appropriate when wide excision would severely compromise the function of the limb. Surgical resections and selective supplementation of adjuvant radiotherapy give excellent control rates.Résumé Nous avons exécuté une analyse rétrospective de 35 cas de tumeurs desmoides (fibromatose agressive) traitées dans notre institution entre 1987 et 2002. Le but était d'évaluer le taux de récidive locale après traitement par excision chirurgicale, d'étudier le rôle des marges chirurgicales sur la récidive et de définir le rôle de la radiothérapie dans le traitement. Neuf malades ont eu une récidive à une moyenne de 16 mois après le traitement initial. Sept des 15 malades opérés avec une marge qui n'était pas large, avait une récidive locale. Comparativement, seulement 2 des 20 malades avec une marge large avaient une récidive locale. Trente trois des 35 malades étaient sans maladie au dernier suivi. Nous recommandons l'excision large avec des marges claires toutes les fois que possible. Les résections marginales sont appropriées quand l'excision large compromettrait sévèrement la fonction du membre. Les résections chirurgicales avec, sélectivement, un traitement adjuvant par radiothérapie donnent d'excellents taux de contrôle de la maladie.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

The management of extra-abdominal desmoid tumours

Duggal

Dickinson

Sommerville

et al. 2004

International Orthopaedics (SICOT)

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“…The few reports of core needle biopsies in the preoperative diagnosis of desmoids suggest that it is a very useful technique (Serpell andPitcher 1998, RayCoquard et al 2003). Recently, there have been suggestions that one should refrain from treatment of many cases of desmoid tumors, with surgical resection being limited to patients with significant symptoms or problematic, potentially life-threatening complications due to the location of the tumor (Dalén et al 2003(Dalén et al , 2006. A correct diagnosis is mandatory in those patients with desmoid who are to be followed rather than to be treated by surgical resection.…”

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confidence: 99%

Fine-needle aspiration cytology and core needle biopsy in the preoperative diagnosis of desmoid tumors

et al. 2006

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Background Desmoid tumors have a tendency to recur locally, and traditionally they have been treated surgically. No treatment is sometimes indicated, however; this requires a morphological diagnosis that is not based on a surgical specimen. In this study we aimed to identify the diagnostic accuracy of needle and core biopsy for the morphological diagnosis of desmoid.Methods We compared the diagnostic accuracy of fine-needle aspiration (FNA) and core needle biopsy (CNB) in 69 and 26 patients, respectively, who had had surgical resections for desmoid. We also reviewed 15 additional cases that had been incorrectly diagnosed as desmoid on FNA but which had different diagnoses after surgery.Results FNA-based diagnoses of desmoid/fibromatosis were rendered in 35 of 69 cases, and other benign spindle cell proliferations in 26 cases and spindle cell sarcoma in the remaining 4 cases. All 26 CNBs were either suggested to correspond to desmoid (24) or other benign spindle cell lesions (2). Of the 15 FNAs incorrectly diagnosed as desmoid, 2 were found to be sarcomas.Interpretation FNA is fairly reliable for recognition of the benign nature of desmoids. Occasional over-and under-diagnosis of malignancy can occur, however. CNB appears to be more reliable.

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“…Wide-margin surgical resection, despite its high rate of recurrence, has traditionally been the first-line treatment option [11]. Huang et al recently reported a univariate analysis showing that admission status (primary/recurrent), gender, tumor size, and margin status are all correlated with local recurrence, while size and margin status were independent prognostic factors in multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

Desmoid Tumor Causing Hip Joint Contracture: A Case Report

Hashimoto¹,

Nishimura²,

Toriumi³

et al. 2018

OJO

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Desmoid tumor (DT) is a relatively uncommon, cytologically bland fibrous neoplasm that is associated with possibility of local recurrence but without the potential to spread to other parts of the body. This disease affects mostly younger adults and is the most common cause of abdominal wall masses in women 20 -35 years of age. However, it may involve nearly every body part, including the extremities, head and neck, trunk, and abdominal cavity; as such, patients with DT may present to a range of general and subspecialty radiologists. The consensus for treatment has changed over the past decade, with most centers moving away from primary radical surgery towards a front-line "wait-and-see" policy. Here, we present a case of a tumor mass that induced hip joint contracture. DT does not usually cause functional disorder. Oncologists should be aware that a desmoid tumor can cause hip joint contracture if the mass occurs in the gluteal region. Moreover, DT resulting in such a functional disorder should be treated by resection.

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Desmoid tumorsA clinical review of 30 patients with more than 20 years’ follow-up

Cited by 73 publications

References 20 publications

The management of extra-abdominal desmoid tumours

The management of extra-abdominal desmoid tumours

Fine-needle aspiration cytology and core needle biopsy in the preoperative diagnosis of desmoid tumors

Desmoid Tumor Causing Hip Joint Contracture: A Case Report

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