Desmoid Tumour of the Breast: Case Report and Review of the Literature

Horevoets, J.; Smet, Bernardo De; Pattyn, Piet; Dorpe, J. van; Vuylsteke, Peter

doi:10.1080/00015458.2013.11680934

Cited by 3 publications

(1 citation statement)

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“…During the last 10 years, the treatment of choice is surgical excision with clear margins,21,22 since these are locally aggressive diseases, as was performed in both of our cases. The positive margin seems to be associated with recurrent disease,23,24 but not all positive margins were recurrent 7,25.…”

Section: Discussionmentioning

confidence: 88%

Bilateral desmoid tumor of the breast: case series and literature review

Wongmaneerung¹,

Somwangprasert²,

Watcharachan³

et al. 2016

IMCRJ

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BackgroundDesmoid tumor of the breast is very rare and locally aggressive but has no distant metastasis. Bilateral lesions are extremely rare, found in only 4% of patients. Two cases of bilateral desmoid tumor of the breast are reported. The clinical presentation, diagnosis, imaging, treatment, and follow-up outcomes of recurrence as well as a brief literature review are provided.Case reportsCase 1 is a 31-year-old woman who presented with nipple retraction. An ultrasound revealed BIRAD V in both breasts. She underwent a bilateral excisional biopsy under ultrasound mark with the pathology result of extra-abdominal desmoid tumor in both breasts. The patient had a bilateral mastectomy with silicone implantation due to the involved margins by excision. She remained tumor free after 7-year follow-up. Case 2 is a 28-year-old woman who presented with a lump on her right breast that she had discovered ~2 months earlier. An ultrasound showed a spiculated mass in the right breast and some circumscribed hypoechoic masses in both breasts. A bilateral breast excision was done. The pathology result was an extra-abdominal desmoid tumor. She had recurrence on both sides and underwent a mastectomy and silicone implantation. The tumor has not recurred after 1-year follow-up.ConclusionImaging cannot distinguish between benign breast lesions and malignancy. Pathology results are helpful in making a definitive diagnosis. Given that the desmoid tumor is locally aggressive, a local excision with clear margins is recommended. Chemotherapy and hormonal treatment are controversial.

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Section: Discussionmentioning

confidence: 88%

Bilateral desmoid tumor of the breast: case series and literature review

Wongmaneerung¹,

Somwangprasert²,

Watcharachan³

et al. 2016

IMCRJ

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The medico-legal observation of an aggressive urogenital fibromatosis with isolated development not related to any traumatic event

Muccino

Gentile

Mantero

et al. 2016

Forensic Science International

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Breast Desmoid Tumours: A Review of the Literature

Wu,

Hughes,

Edirimanne

et al. 2024

The Breast Journal

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Breast desmoid tumour is a rare type of benign breast disease that presents like malignancy. Current guidelines are based on limited evidence derived from case reports and small case series and recommend resection with microscopically‐negative margin (R0). There is a high risk of recurrence despite negative surgical margins. A review of the published cases of breast desmoid since 2000 was conducted using Medline and Embase to descriptively analyse the clinical presentation, diagnosis, treatment, and outcomes of this rare disease. After screening, we identified 46 patients from 39 articles. Most cases did not have risk factors, but 17/46 (37%) had prior procedures on the ipsilateral breast. Mammography was able to detect 65% of the cases, ultrasound detected 74%, and both CT and MRI detected all cases when used. Preoperative diagnosis was best performed using core needle biopsy showing typical histology and positive beta‐catenin staining. 42/46 cases underwent definitive surgical management, with 8 cases of recurrence. Recurrence occurred within 3 years of the initial surgery. Median time of recurrence was 8 months, and the median follow‐up of the recurrence‐free patients was 12 months. There were no predictive factors identified for recurrence. There were 7 cases treated with a nonsurgical modality, with 3 showing at least a partial response.

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Desmoid Tumour of the Breast: Case Report and Review of the Literature

Cited by 3 publications

References 0 publications

Bilateral desmoid tumor of the breast: case series and literature review

Bilateral desmoid tumor of the breast: case series and literature review

The medico-legal observation of an aggressive urogenital fibromatosis with isolated development not related to any traumatic event

Breast Desmoid Tumours: A Review of the Literature

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