Desmoplastic Fibroblastoma (Collagenous Fibroma)

Abstract

Desmoplastic fibroblastoma is a vary rare subcutaneous proliferation. We describe a case of desmoplastic fibroblastoma in a 24-year-old Korean woman who presented with a 2.5 cm solitary and firm nodule on her back which had been present for 3 months. Histologic studies showed a well demarcated subcutaneous tumor composed of stellate or spindle shaped cells embedded in hypovascular fibrous or fibromyxoid stroma. No mitotic figures, calcification, or necrosis were observed. The stellate or spindle shaped cells were positive for vimentin. The stroma stained positively with Alcian blue and Masson trichrome. S-100 protein, actin, desmin, and elastic fiber stains were all negative in the stellate or spindle shaped cells. There has been no recurrence or metastasis of the tumor over an 18-month follow-up.

Desmoplastic Fibroblastoma (Collagenous Fibroma): A Case Identified in the Buccal Mucosa

“…Microscopically, DF is characterized by a paucicellular proliferation of spindle to stellate-shaped cells, embedded in a highly hyalinized collagenous stroma with or without focal fibromyxoid degeneration [4]. Binucleation [3,6] and a few multinucleated giant cells can be observed in some reports [1,3,[20][21][22], as was the case in the present study. However, future research concerning the exact origin of multinucleated giant cells is warranted.…”

“…The majority of studies containing a-smooth muscle actin have shown that lesional cells are focally positive [3, 5, 6, 19-21, 23, 24]. However, as occurred in the present research, other studies have also reported negative a-smooth muscle actin [1,22,25,26]. Factor XIIIa proved to be positive in only a few selected cells [3,6,26], while negative staining could be observed in one study [1].…”

“…DF is strong and diffusely positive to vimentin [1,3,[5][6][7][19][20][21][22][23][24][25] and preferably negative to S-100 protein [1, 3, 5-7, 20, 22-26], CD34 [1,3,5,7,[19][20][21][22][23][24][25][26], desmin [1,3,19,[22][23][24][25][26], cytokeratins [1,19,21,24,25], epithelial membrane antigen [21,[23][24][25], and CD68 [1,3,20,23]. The majority of studies containing a-smooth muscle actin have shown that lesional cells are focally positive [3, 5, 6, 19-21, 23, 24].…”

“…Treatment of DF is performed by complete excision and, although to date neither recurrences nor metastasis have been reported [1][2][3][4][5][6][7][19][20][21][22][23][24][25][26], it is important to know the characteristics of this rare condition in an attempt to prove differential diagnoses when compared to other oral lesions.…”

A Rare Localization of Desmoplastic Fibroblastoma: Chest Wall

“…It usually appears in various locations, including the upper extremities, posterior neck, upper back, lower extremities, abdominal wall and hip. The tumor ranges in size from 1 to 20 cm in maximum dimension [3,4]. Entrapment of the adjacent muscle and fat is common, but aggressive growth is not a feature of desmoplastic fibroblastoma [1,3,5].…”