Desmoplastic fibroma of bone

Abstract

Desmoplastic fibroma is a rare primary tumor of bone that histologically and biologically mimics the extra‐abdominal desmoid tumor of soft tissue. This study reviews 27 cases of desmoplastic fibroma, consisting of 9 from the Mayo Clinic files and 18 from our consultation files. There was a male predominance, and 74% of the patients were in the first 3 decades of life. The most frequent sites of involvement were the metaphysis of long bones and the mandible. Radiographically, the tumors were lucent, expansile lesions with well‐defined margins. Histologically, they contained slender spindle cells and various amounts of collagen fibers. En bloc resection is the treatment of choice because a high incidence of recurrence was noticed after lesional curettage.

Desmoplastic Fibroma : Mandible

“…Nonossifying fibroma and solitary congenital fibromatosis of bone can be confused with desmoplastic fibroma. Low grade fibrosarcoma poses the most difficult problem in the histologic differential diagnosis; in fact, the distinction may not always be possible and can only be detected when it recurs and metastasizes [5]. However, fibrosarcoma is more cellular, with a recognizable herringbone pattern and plumper, larger cells than those in desmoplastic fibroma.…”

Radiotherapy for Desmoplastic Fibroma of Bone: A Case Report

“…3 Although the tumour has been described in various locations of the body, it most commonly arises in the metaphyseal region of long bones. 3 The lesion arises within the central portion of the bone and grows outwards. There is no radiographic evidence of matrix mineralisation.…”

Incidental lesion in the femoral metaphysis

“…It may involve almost any bone in the skeletal system, most frequently affecting the metaphysis of long bones and the mandible. Though the tumor is benign, it has a propensity towards local infiltration [1]. Clinically, the commonest presentation is pain, palpable mass, and swelling; although it may be discovered as incidental finding on imaging.…”

“…A radiologist must be vigilant in the recognition of this entity due to its characteristic imaging appearance, otherwise it may be confused with other benign fibrous lesions or more importantly, sarcoma [1]. On radiographs, the matrix appears nonmineralized with coarse ridge-like internal trabeculations ( Fig.…”