Desmoplastic fibroma of the skull

Abstract

Desmoplastic fibroma is a primary bone tumour which occurs exceedingly rarely in the cranial bones. We report a histopathologically confirmed example in a 21 year old man with a painless swelling over the sagittal suture. In the light of our experience and reports of previous examples, we review the features of the condition and its management.

1 Case Clinical Report of Cranium Aggressive Fibromatosis and Literature Review

“…In addition, research indicated that there existed a great deal of estrogen and progestogen. This notion had not been confirmed in this cranium AF case study [9] [10].…”

“…5) Periapical fibroma of cranium: this diseases in commonly implicated to bones apart from the cranium, such as appendicular skeletons. The CT scan displaying ground glass-like is the main characterization to distinguish it with AF [9]. In this study, this patient case did error diagnosed as the periapical fibroma of cranium.…”

“…The AF cells always turn out to be fusiform shape with small and round nuclei, heteromorphism was not found [8] [11]. As for immunophenotype, tumor cells could express Vim or SMA, Des now and then, but not actin and S-100 [9] [10]. Recent studies [12]- [14] found that β-catenin positive expression had high sensitive in AF diagnosis and differential diagnosis, thereby is considered as a critical index for judgment in diagnosis.…”

“…3) Fibroblast type of meningioma: this disease has similar manifestation of chinical symptom, iconography, component and morphology of tumor cell with cranium AF. Immunohistochemistry displaying positive EMA expression is the major distinguishable main point [9]. 4) Cranium skeletal angiomatosis, which has a similar manifestation in X plain scan and CT, but MRI T2 weight image showing "black-ringed" that the hypointensity patches containing hemosiderin around the tumor is the most characteristic distinguishable hotspot [17].…”

Desmoplastic Fibroma of the Cranium in a Young Man

“…DF in the cranium is extremely rare. Since the first report by Gardini et al7) in 1978, fewer than 20 cases have been described in the literature5,11,14). In this report, we present a case of DF in the cranium.…”