Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes

Nekrasova, Oxana; Amargo, Evangeline V.; Smith, William O.; Chen, Jing; Kreitzer, Geri; Green, Kathleen J.

doi:10.1083/jcb.201106057

Cited by 90 publications

(75 citation statements)

References 73 publications

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“…Recent studies implicate the microtubule network and kinesin motor proteins in transporting desmogleins and desmocollins to sites of cell adhesion [45]. Interestingly, desmocollin delivery to the membrane requires kinesin-2, whereas desmoglein transport is dependent upon kinesin-1.…”

Section: Making and Breaking Desmosomes: Regulation Of Adhesive Smentioning

confidence: 99%

Structure, Function, and Regulation of Desmosomes

Kowalczyk¹,

Green²

2013

Progress in Molecular Biology and Translational Science

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222

207

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Summary Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate filament cytoskeletal network. Desmosomal cadherins are connected to intermediate filaments by densely clustered cytoplasmic plaque proteins comprising members of the armadillo gene family, including plakoglobin and plakophilins, and members of the plakin family of cytolinkers, such as desmoplakin. The importance of desmosomes in tissue integrity is highlighted by human diseases caused by mutations in desmosomal genes, autoantibody attack of desmosomal cadherins, and bacterial toxins that selectively target desmosomal cadherins. In addition to reviewing the well-known roles of desmosomal proteins in tissue integrity, this chapter also highlights the growing appreciation for how desmosomal proteins are integrated with cell signaling pathways to contribute to vertebrate tissue organization and differentiation.

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Section: Making and Breaking Desmosomes: Regulation Of Adhesive Smentioning

confidence: 99%

Structure, Function, and Regulation of Desmosomes

Kowalczyk¹,

Green²

2013

Progress in Molecular Biology and Translational Science

Self Cite

222

207

View full text Add to dashboard Cite

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“…Plakoglobin in turn binds a member of the plakin family, desmoplakin, which binds directly to cytokeratin intermediate filaments (Hudson et al 2004). Plakophilin is required for kinesin-2-dependent recruitment of Dsc2 to the plasma membrane (Nekrasova et al 2011), and forms a scaffolding complex containing desmoplakin and protein kinase C-alpha, which regulates the strength of interactions between desmoplakin and intermediate filaments to facilitate junctional integrity (Nekrasova et al 2011; Bass-Zubek et al 2008). …”

Section: Introductionmentioning

confidence: 99%

Cell–Cell Junctions Organize Structural and Signaling Networks

García

Nelson

Chavez

2017

Cold Spring Harb Perspect Biol

360

253

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Cell-cell junctions link cells to each other in tissues, and regulate tissue homeostasis in critical cell processes that include tissue barrier function, cell proliferation and migration. Defects in cell-cell junctions give rise to a wide range of tissue abnormalities that disrupt homeostasis and are common in genetic abnormalities and cancers. Here, we discuss the organization and function of cell-cell junctions primarily involved in adhesion (Tight Junction, Adherens Junction, and Desmosomes) in two different epithelial tissues: a simple epithelium (intestine) and a stratified epithelium (epidermis). Studies in these tissues reveal similarities and differences in the organization and functions of different cell-cell junctions that meet the requirements for the specialized functions of each tissue. We discuss cell-cell junction responses to genetic and environmental perturbations that provide further insights into their roles in maintaining tissue homeostasis.

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“…According to the present view, desmosomal cadherins in association with plakoglobin are transported by kinesinmediated vesicular traffic (Burdett & Sullivan, 2002). Interestingly, vesicular transport of different desmosomal cadherins depends on distinct kinesins (Dsg2-kinesin-1; Dsc2-kinesin-2) (Nekrasova et al, 2011). DP and PKP2 play an important role in desmosomal cadherin association with IFs and assembly into cell-cell contact sites (Bass-Zubek et al, 2008;Godsel et al, 2005).…”

Section: Impaired Transport Targeting and Assembly Into Mature Desmmentioning

confidence: 86%

150th Anniversary Series: Desmosomes and the Hallmarks of Cancer

Huber

Petersen

2015

Cell Communication & Adhesion

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Desmosomes represent adhesive, spot-like intercellular junctions that in association with intermediate filaments mechanically link neighboring cells and stabilize tissue architecture. In addition to this structural function, desmosomes also act as signaling platforms involved in the regulation of cell proliferation, differentiation, migration, morphogenesis, and apoptosis. Thus, deregulation of desmosomal proteins has to be considered to contribute to tumorigenesis. Proteolytic fragmentation and downregulation of desmosomal cadherins and plaque proteins by transcriptional or epigenetic mechanisms were observed in different cancer entities suggesting a tumor-suppressive role. However, discrepant data in the literature indicate that context-dependent differences based on alternative intracellular, signal transduction lead to altered outcome. Here, modulation of Wnt/β-catenin signaling by plakoglobin or desmoplakin and of epidermal growth factor receptor signaling appears to be of special relevance. This review summarizes current evidence on how desmosomal proteins participate in carcinogenesis, and depicts the molecular mechanisms involved.

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Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes

Abstract: Desmogleins and desmocollins are transported to the plasma membrane by different kinesin motors, providing a potential mechanism to tailor desmosome structure and function during development and epithelial remodeling.

Cited by 90 publications

References 73 publications

Structure, Function, and Regulation of Desmosomes

Structure, Function, and Regulation of Desmosomes

Cell–Cell Junctions Organize Structural and Signaling Networks

150th Anniversary Series: Desmosomes and the Hallmarks of Cancer

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