1999
DOI: 10.1007/s002580050281
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Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues

Abstract: Plakophilin 2 (PKP2) is a widespread protein which shows a remarkable dual location: On the one hand, it appears as a constitutive karyoplasmic protein and on the other it is a desmosomal plaque component of most, probably all, desmosome-possessing tissues and cell culture lines. Here we report on its desmosomal occurrence as revealed by immunocytochemical results obtained with three PKP2-specific murine monoclonal antibodies (mAbs) PP2-62, PP2-86 and PP2-150. These mAbs detect PKP2 in characteristic desmosome… Show more

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Cited by 41 publications
(73 citation statements)
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“…Moreover, in a wide range of different kinds of cells lacking desmosomes including fibroblasts, lymphocytes, and chicken erythrocytes, plakophilins have been detected exclusively in the nucleus (6,7,10,11). This finding suggests that plakophilins are constitutive nuclear proteins that, in certain pathways of cell differentiation, are recruited to a second specific location in desmosomal plaques (6)(7)(8)(9).…”
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confidence: 92%
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“…Moreover, in a wide range of different kinds of cells lacking desmosomes including fibroblasts, lymphocytes, and chicken erythrocytes, plakophilins have been detected exclusively in the nucleus (6,7,10,11). This finding suggests that plakophilins are constitutive nuclear proteins that, in certain pathways of cell differentiation, are recruited to a second specific location in desmosomal plaques (6)(7)(8)(9).…”
mentioning
confidence: 92%
“…[18][19][20][21]. Among them one was identified as a Ϸ100-kDa polypeptide corresponding in size to plakophilin 2 (6)(7)(8). Indeed, immunoblot analysis (Fig.…”
Section: Plakophilin 2-containing Complexesmentioning
confidence: 99%
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