This investigation delves into the enhancement of heat exchange efficiency in heat exchange stations employing large temperature differential absorption (LTDA) heat pumps, a challenge often attributed to suboptimal operational adjustments. The focus is placed on LTDA heat pump systems within these stations, where operational adjustments are meticulously modified. The criterion for evaluation, energy efficiency, is rigorously applied throughout. A comprehensive approach combining experimental research with data simulation has been adopted, leading to the establishment of a mathematical model for the unit. Utilizing Matlab software, the simulation of adjustment methods for both the primary and secondary sides of the system is conducted in a phased manner, aiming to identify the most favorable operating conditions across various adjustment methods. Findings from this study reveal that the activation of lithium bromide absorption heating units for volume adjustment on the system's secondary side markedly underperforms in terms of heat exchange efficiency when compared to both mass adjustment and massvolume adjustment strategies. Crucially, it is identified that superior operating conditions under varying adjustment methods are achieved when the primary side supply water temperature is maintained at 110°C, coupled with a 20% ratio of temperature-driven heat exchanger flow to the actual flow on the secondary side, culminating in a peak heat exchange efficiency of 2.18. These results guide LTDA heat pump operational strategies in heat exchange stations, stressing strategic adjustments for better energy efficiency.