In recent years, various environmental issues have aroused a concern on the pollution of pesticides in rivers and in their various intercompartments. Multiple residues of pesticides discharged from industries or as a result of extensive use of agrochemicals in agriculture have been monitored. These pesticide residues contaminate the river ecosystem and its intercompartments such as sediments, and aquatic biota, and make it harmful to humans when they contaminate food and drinking water. The pesticide contamination in water, sediments, and aquatic biota has been reported to be beyond the acceptable range. The most commonly found pesticides are organochlorine, namely, dichlorodiphenyltrichloroethane, hexachlorocyclohexane, endosulfan, heptachlor, lindane, dieldrin, aldrin, endrin, and others. The paper discusses the general description, classification, and toxicity of pesticides; it also aims to create public awareness among people and appraise them with various alternate methods to combat the problem of pesticide contamination. An attempt has also been made to elucidate the findings of various works on pesticides in aquatic system and to highlight the challenging aspects of pesticide contamination, which have not attracted the attention of investigators yet.