Destabilizing effect of perfluorodecanoic acid on simple membrane models

Viada, Benjamín Nahuel; Cámara, Candelaria Inés; Yudi, Lidia Mabel

doi:10.1039/c8sm02301h

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…1,2 However, their specific properties, such as stability, has led to the persistence of PFAS in the environment (soil, water), as well as in wildlife and humans. 3,4,5,6,7,8 This raises environmental and human health concerns due to the toxicity and bioaccumulation of PFAS. Taking into account this hazard, it is important to monitor the presence and concentrations of PFAS.…”

Section: Introductionmentioning

confidence: 99%

Detection of perfluorooctane sulfonate by ion-transfer stripping voltammetry at an array of microinterfaces between two immiscible electrolyte solutions

Viada

Yudi

Arrigan

2020

Analyst

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Section: Introductionmentioning

confidence: 99%

Detection of perfluorooctane sulfonate by ion-transfer stripping voltammetry at an array of microinterfaces between two immiscible electrolyte solutions

Viada

Yudi

Arrigan

2020

Analyst

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“…This lipid is an essential component in the cell membrane’s ability to form membrane fusion structures (lipidmaps.org). PFOS has been shown to decrease multiple types of phospholipids in mouse kidney, including PAs and PEs [ 98 ], and this may be due to the degradation of the membrane protein components, resulting in membrane leakage and variation in rigid structure [ 99 , 100 , 101 ]. One recent study using injection of PFOS into zebrafish embryos at levels equal to and lower than those in this study found very similar results, with Yang et al [ 85 ] showing downregulation of PE and PCs in zebrafish embryos after PFOS exposure.…”

Section: Discussionmentioning

confidence: 99%

Per- and Polyfluoroalkyl Substances: Impacts on Morphology, Behavior and Lipid Levels in Zebrafish Embryos

Albers,

Mylroie,

Kimble

et al. 2024

Toxics

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The presence of per- and polyfluoroalkyl substances (PFASs) in aquatic environments is often persistent and widespread. Understanding the potential adverse effects from this group of chemicals on aquatic communities allows for better hazard characterization. This study examines impacts on zebrafish (Danio rerio) embryo physiology, behavior, and lipid levels from exposure to perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), and heptadecafluorooctanesulfonic acid (PFOS). Embryos were exposed to lethal and sublethal levels of each chemical and monitored for alterations in physiological malformations, mortality, lipid levels, and behavior (only PFOA and PFHxS). The predicted 50% lethal concentrations for 120 hpf embryos were 528.6 ppm PFOA, 14.28 ppm PFHxS, and 2.14 ppm PFOS. Spine curvature and the inability of the 120 hpf embryos to maintain a dorsal-up orientation was significantly increased at 10.2 ppm PFHxS and 1.9 ppm PFOS exposure. All measured 120 hpf embryo behaviors were significantly altered starting at the lowest levels tested, 188 ppm PFOA and 6.4 ppm PFHxS. Lipid levels decreased at the highest PFAS levels tested (375 PFOA ppm, 14.4 PFHxS ppm, 2.42 ppm PFOS). In general, the PFAS chemicals, at the levels examined in this study, increased morphological deformities, embryo activity, and startle response time, as well as decreased lipid levels in 120 hpf zebrafish embryos.

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“…36 We propose that anionic PFHA − is depleted from the protonated-DPPG interface because of repulsive interaction between their fluoroalkyl and alkyl chains. Surface tensiometry and Brewster angle microscopy 69 of anionic (distearoyl phosphatidic acid) lipid monolayer have also revealed that perfluoro decanoic acid is expelled from the anionic lipid monolayer interface at higher surface pressure (above 20 mN/m) but coexists with the lipid at lower surface pressure. In the following section, we have examined the headgroup-specific interaction of PFHA at zwitterionic DPPC/ water interface where anionic phosphate and cationic choline groups coexist at the interface.…”

Section: Ssmentioning

confidence: 99%

Headgroup-Specific Interaction of Biological Lipid Monolayer/Water Interface with Perfluorinated Persistent Organic Pollutant (f-POP): As Observed with Interface-Selective Vibrational Spectroscopy

2022

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Perfluoro compounds are widely used in various manufacturing processes, which leads to their bioaccumulation and subsequent adverse effects on human health. Using interface-selective vibrational spectroscopy (heterodyne-detected vibrational sum frequency generation (HD-VSFG)), we have elucidated the molecular mechanism of the perturbation of lipid monolayers on the water surface using a prototype perfluorinated persistent organic pollutant, perfluoroheptanoic acid (PFHA). PFHA disrupts the well-ordered all-trans conformation of a cationic lipid (1,2-dipalmitoyl-3-trimethylammonium propane (DPTAP)) monolayer and reduces the interfacial electric field at the lipid/water interface. In contrast, the hydrophobic packing of an anionic lipid (1,2-dipalmitoyl-sn-glycero-3-phospoglycerol (DPPG)) monolayer remains largely unaffected in the presence of PFHA, though the interfacial electric field is reduced. For a zwitterionic lipid (1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC))/water interface, both alkyl chain ordering and interfacial electric field are fairly perturbed by PFHA. Lipid headgroup-specific interaction of PFHA and the repulsive interaction of oleophobic fluoroalkyl chain with the lipid alkyl chains govern these distinct perturbations of the lipid monolayers on the water surface.

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Destabilizing effect of perfluorodecanoic acid on simple membrane models

Cited by 9 publications

References 50 publications

Detection of perfluorooctane sulfonate by ion-transfer stripping voltammetry at an array of microinterfaces between two immiscible electrolyte solutions

Detection of perfluorooctane sulfonate by ion-transfer stripping voltammetry at an array of microinterfaces between two immiscible electrolyte solutions

Per- and Polyfluoroalkyl Substances: Impacts on Morphology, Behavior and Lipid Levels in Zebrafish Embryos

Headgroup-Specific Interaction of Biological Lipid Monolayer/Water Interface with Perfluorinated Persistent Organic Pollutant (f-POP): As Observed with Interface-Selective Vibrational Spectroscopy

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