We consider gedanken experiments to destroy an extremal or nearly extremal Kerr-Newman black hole by causing it to absorb matter with sufficient charge and/or angular momentum as compared with energy that it cannot remain a black hole. It was previously shown by one of us that such gedanken experiments cannot succeed for test particle matter entering an extremal Kerr-Newman black hole. We generalize this result here to arbitrary matter entering an extremal Kerr-Newman black hole, provided only that the non-electromagnetic contribution to the stressenergy tensor of the matter satisfies the null energy condition. We then analyze the gedanken experiments proposed by Hubeny and others to over-charge and/or over-spin an initially slightly non-extremal Kerr-Newman black hole. Analysis of such gedanken experiments requires that we calculate all effects on the final mass of the black hole that are second-order in the charge and angular momentum carried into the black hole, including all self-force effects. We obtain a general formula for the full second order correction to mass, δ 2 M , which allows us to prove that no gedanken experiments of the generalized Hubeny type can ever succeed in over-charging and/or over-spinning a Kerr-Newman black hole, provided only that the non-electromagnetic stress-energy tensor satisfies the null energy condition. Our analysis is based upon Lagrangian methods, and our formula for the second-order correction to mass is obtained by generalizing the canonical energy analysis of Hollands and Wald to the Einstein-Maxwell case. Remarkably, we obtain our formula for δ 2 M without having to explicitly compute self-force or finite size effects. Indeed, in an appendix, we show explicitly that our formula incorporates both the self-force and finite size effects for the special case of a charged body slowly lowered into an uncharged black hole.2